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Cardiovascular Blood Platelets

FITC荧光Anti-Fibrinogen抗体(ab4217)

  • Datasheet
  • SDS
Reviews (1)Q&A (1)References (1)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Fibrinogen antibody (ab4217)

    Key features and details

    • FITC Rabbit polyclonal to Fibrinogen
    • Suitable for: IHC-P, ICC/IF
    • Reacts with: Human
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG

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    概述

    • 产品名称

      FITC荧光Anti-Fibrinogen抗体
      参阅全部 Fibrinogen 一抗
    • 描述

      FITC荧光兔多克隆抗体to Fibrinogen
    • 宿主

      Rabbit
    • 偶联物

      FITC. Ex: 493nm, Em: 528nm
    • 特异性

      This antibody reacts with native fibrinogen as well as with the fibrinogen fragments D, E, X and Y.
    • 经测试应用

      适用于: IHC-P, ICC/IFmore details
    • 种属反应性

      与反应: Human
    • 免疫原

      Full length native protein (purified) corresponding to Human Fibrinogen. Fibrinogen isolated from human plasma.
      Database link: P02671

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Store at +4°C.
    • 存储溶液

      pH: 7.3
      Preservative: 0.05% Sodium azide
      Constituent: 1% BSA
    • Concentration information loading...
    • 纯度

      IgG fraction
    • 纯化说明

      Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins.
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Cardiovascular
      • Blood
      • Platelets
      • Cardiovascular
      • Blood
      • Coagulation
      • Common
      • Cardiovascular
      • Atherosclerosis
      • Thrombosis
      • Other
      • Metabolism
      • Types of disease
      • Metabolic disorders

    相关产品

    • Isotype control

      • FITC-Rabbit IgG - Isotype Control (ab37406)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab4217于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    IHC-P
    Use at an assay dependent concentration.
    ICC/IF
    Use at an assay dependent concentration.
    说明
    IHC-P
    Use at an assay dependent concentration.
    ICC/IF
    Use at an assay dependent concentration.

    靶标

    • 功能

      Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    • 组织特异性

      Plasma.
    • 疾病相关

      Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
      Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
    • 序列相似性

      Contains 1 fibrinogen C-terminal domain.
    • 结构域

      A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
    • 翻译后修饰

      The alpha chain is not glycosylated.
      Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
      About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
      Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
      Phosphorylation sites are present in the extracellular medium.
    • 细胞定位

      Secreted.
    • Target information above from: UniProt accession P02671 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 2243 Human
      • Entrez Gene: 2244 Human
      • Entrez Gene: 2266 Human
      • Omim: 134820 Human
      • Omim: 134830 Human
      • Omim: 134850 Human
      • SwissProt: P02671 Human
      • SwissProt: P02675 Human
      • SwissProt: P02679 Human
      • Unigene: 351593 Human
      see all
    • 别名

      • FGA antibody
      • FGB antibody
      • FGG antibody
      • Fib2 antibody
      • FIBA_HUMAN antibody
      • Fibrinogen A alpha polypeptide antibody
      • Fibrinogen alpha chain antibody
      • Fibrinogen B alpha polypeptide antibody
      • Fibrinogen beta chain antibody
      • Fibrinogen G alpha polypeptide antibody
      • Fibrinogen gamma chain antibody
      • fibrinogen, B beta polypeptide antibody
      • fibrinogen, G gamma polypeptide antibody
      • fibrinogen, gamma polypeptide antibody
      • Fibrinogen--alpha -polypeptide chain antibody
      • Fibrinogen--beta -polypeptide chain antibody
      • Fibrinogen--gamma-polypeptide chain antibody
      see all

    图片

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Fibrinogen antibody (ab4217)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-Fibrinogen antibody (ab4217)

      Immunohistochemical analysis of Formalin-fixed paraffin-embedded human placenta labeling Fibrinogen with ab4217 (left -low magnification; and right - high magnification).

    实验方案

    • Immunohistochemistry protocols

    Click here to view the general protocols

    数据表及文件

    • SDS download

    • Datasheet download

      Download

    文献 (1)

    发表研究结果有使用 ab4217?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab4217 被引用在 1 文献中.

    • Jiménez JM  et al. Macro- and microscale variables regulate stent haemodynamics, fibrin deposition and thrombomodulin expression. J R Soc Interface 11:20131079 (2014). PubMed: 24554575

    客户评价及客户问答

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    1-2 of 2 Abreviews or Q&A

    Flow Cytometry abreview for Anti-Fibrinogen antibody (FITC)

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Flow Cytometry
    Sample
    Human Cell (platelets (platelet rich plasma))
    Permeabilization
    No
    Gating Strategy
    platelets were gated
    Specification
    platelets (platelet rich plasma)
    Preparation
    Cell harvesting/tissue preparation method: apheresis platelet product, activated with ristocetin.
    Sample buffer: HEPES-Tyrode's, pH 7.2
    Fixation
    none
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Dianne Van Der Wal

    Verified customer

    提交于 Jul 12 2016

    Question

    What is the Fluorescein:antibody molar ratio of ab4217?

    Read More

    Abcam community

    Verified customer

    Asked on Nov 03 2003

    Answer

    Thank you for your enquiry. The molar ratio is 2.3.

    Read More

    Abcam Scientific Support

    回复于 Nov 05 2003

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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