FITC荧光Anti-DR5抗体[DR5-01-1] (ab53319)
![Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)](https://www.abcam.cn/ps/products/53/ab53319/Images/ab53319-454768-FITC-AntiDR5-antibody-Flow.jpg "Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)")
Key features and details
- FITC Mouse monoclonal [DR5-01-1] to DR5
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-DR5抗体[DR5-01-1]
参阅全部 DR5 一抗 -
描述
FITC荧光小鼠单克隆抗体[DR5-01-1] to DR5 -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
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常规说明
The reagent is free of unconjugated FITC.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.2% BSA, PBS -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
DR5-01-1 -
同种型
IgG1 -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab53319于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use a concentration of 1 - 5 µg/ml.
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| 说明 |
|---|
|
Flow Cyt
Use a concentration of 1 - 5 µg/ml. |
靶标
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功能
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. -
组织特异性
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. -
疾病相关
Squamous cell carcinoma of the head and neck -
序列相似性
Contains 1 death domain.
Contains 3 TNFR-Cys repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 8795 Human
- Omim: 603612 Human
- SwissProt: O14763 Human
- Unigene: 521456 Human
- Unigene: 661668 Human
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别名
- Fas like protein antibody
- Apoptosis inducing protein TRICK2A/2B antibody
- Apoptosis inducing receptor TRAIL R2 antibody
see all
图片
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Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (ab53319)
Flow cytometry analysis (surface staining) of CD262 on CD262-transfectants using ab53319 at 5 μg/ml.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab53319 被引用在 2 文献中.
- Strekalova E et al. Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction. Methods Mol Biol 1866:61-73 (2019). PubMed: 30725408
- Pan L et al. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell 176:1477-1489.e14 (2019). PubMed: 30827683