FITC荧光Anti-Dectin-1抗体[2A11] (ab21646)
![Flow Cytometry - FITC Anti-Dectin-1 antibody [2A11] (ab21646)](https://www.abcam.cn/ps/products/21/ab21646/Images/ab21646-30690-anti-beta-glucan-receptor-antibody-2a11-fitc-flow-cytometry.jpg "Flow Cytometry - FITC Anti-Dectin-1 antibody [2A11] (ab21646)")
Key features and details
- FITC Rat monoclonal [2A11] to Dectin-1
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2b
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-Dectin-1抗体[2A11]
参阅全部 Dectin-1 一抗 -
描述
FITC荧光大鼠单克隆抗体[2A11] to Dectin-1 -
宿主
Rat -
偶联物
FITC. Ex: 493nm, Em: 528nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant full length protein. This information is proprietary to Abcam and/or its suppliers.
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常规说明
This antibody inhibits the binding of zymosan to macrophages via the beta Glucan Receptor.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
纯度
Protein G purified -
Primary antibody说明
This antibody inhibits the binding of zymosan to macrophages via the beta Glucan Receptor. -
克隆
单克隆 -
克隆编号
2A11 -
骨髓瘤
Y3/Ag1.2.3 -
同种型
IgG2b -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab21646于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt | (1) |
Use 10µl for 106 cells.
Use 10µl for 106 cells in 100µl.
ab136125 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
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| 说明 |
|---|
|
Flow Cyt
Use 10µl for 106 cells. Use 10µl for 106 cells in 100µl.
ab136125 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
|
靶标
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功能
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. -
组织特异性
Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. -
疾病相关
Defects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
序列相似性
Contains 1 C-type lectin domain. -
翻译后修饰
Phosphorylated on tyrosine residues in response to glucan binding. -
细胞定位
Cytoplasm and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 56644 Mouse
- SwissProt: Q6QLQ4 Mouse
- Unigene: 239516 Mouse
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别名
- Beta GR antibody
- Beta-glucan receptor antibody
- BGR antibody
see all
图片
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Flow Cytometry - FITC Anti-Dectin-1 antibody [2A11] (ab21646)Flow cytometry staining of mouse peripheral blood granulocytes with ab21646.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab21646 被引用在 2 文献中.
- Tang C et al. Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression. Nat Commun 14:1493 (2023). PubMed: 36932082
- Daley D et al. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat Med 23:556-567 (2017). IHC-Fr, Flow Cyt ; Mouse . PubMed: 28394331