FITC荧光Anti-CD8 alpha抗体[3-298] (ab24910)
![Flow Cytometry - Anti-CD8 alpha antibody [3-298] (FITC) (ab24910)](https://www.abcam.cn/ps/products/24/ab24910/Images/ab24910-1-anti-cd8-alpha-antibody-3-298-fitc-flow-cytometry-peripheral-blood-lymphocytes-chicken.jpg "Flow Cytometry - Anti-CD8 alpha antibody [3-298] (FITC) (ab24910)")
Key features and details
- FITC Mouse monoclonal [3-298] to CD8 alpha
- Suitable for: Flow Cyt
- Reacts with: Chicken
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2b
概述
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产品名称
FITC荧光Anti-CD8 alpha抗体[3-298]
参阅全部 CD8 alpha 一抗 -
描述
FITC荧光小鼠单克隆抗体[3-298] to CD8 alpha -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
This antibody recognises CD8a. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Chicken
预测可用于: Turkey
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免疫原
Tissue, cells or virus corresponding to CD8 alpha. Chicken thymocytes
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阳性对照
- Flow Cyt: Chicken peripheral blood lymphocytes.
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常规说明
In chicken, the CD8 molecule is present in two forms: (i) a homodimer of two alpha chains, and (ii) a heterodimer of an alpha chain and a beta chain. Chicken CD8 is expressed on approximately 80% of thymocytes, 45% of blood mononuclear cells and 50% of spleen cells, but <1% of cells in the bursa and bone marrow. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8 alpha and CD8 beta chains, a relatively large proportion of the CD8+ TCR gamma delta cells in the spleens of embryos and young chicks express only the alpha chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved, but there is a population of TCR gamma delta CD8 alpha beta cells in the chicken that is not found in rodents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Store In the Dark. -
存储溶液
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Affinity purified -
Primary antibody说明
In chicken, the CD8 molecule is present in two forms: (i) a homodimer of two alpha chains, and (ii) a heterodimer of an alpha chain and a beta chain. Chicken CD8 is expressed on approximately 80% of thymocytes, 45% of blood mononuclear cells and 50% of spleen cells, but <1% of cells in the bursa and bone marrow. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8 alpha and CD8 beta chains, a relatively large proportion of the CD8+ TCR gamma delta cells in the spleens of embryos and young chicks express only the alpha chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved, but there is a population of TCR gamma delta CD8 alpha beta cells in the chicken that is not found in rodents. -
克隆
单克隆 -
克隆编号
3-298 -
同种型
IgG2b -
轻链类型
kappa -
研究领域
相关产品
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab24910于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. |
靶标
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功能
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. -
疾病相关
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. -
序列相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻译后修饰
All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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别名
- alpha polypeptide (p32) antibody
- CD_antigen=CD8a antibody
- CD8 antibody
see all
图片
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Flow Cytometry - Anti-CD8 alpha antibody [3-298] (FITC) (ab24910)
Chicken peripheral blood lymphocytes were costained using CD8 alpha-FITC and CD4-PE to distinguish cell subpopulations. Cells were incubated with anti-CD8 alpha antibody [3-298] (FITC) (ab24910) at 1 µg/106 cells.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab24910 尚未被引用在任何文献中。