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AB18240

FITC Anti-CD45RA 抗体 [MEM-56]

FITC Anti-CD45RA antibody [MEM-56]

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(3 Publications)

Mouse Monoclonal CD45 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing PTPRC protein.

查看别名

CD45, PTPRC, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, L-CA

1 Images
Flow Cytometry - FITC Anti-CD45RA antibody [MEM-56] (AB18240)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD45RA antibody [MEM-56] (AB18240)

Flow cytometry analysis of human peripheral blood cells labeling CD45RA with ab18240.

不同偶联物与剂型 (3)

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

MEM-56

亚型

IgG2b

偶联物

FITC

激发波长/发射波长

Ex: 495nm, Em: 519nm

不含载体蛋白

No

反应种属

Human

应用

Flow Cyt

applications

免疫原

Cell preparation containing PTPRC protein. The exact immunogen used to generate this antibody is proprietary information.

P08575

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/fitc-mouse-igg2b-plpv219-isotype-control-ab91368'>ab91368</a> - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.</p>" } } }
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产品详情

The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: BSA, PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD45RA also known as CD45RA antigen and T200 is an isoform of the CD45 protein family. It is a transmembrane protein tyrosine phosphatase with a molecular mass of approximately 220 kDa. CD45RA expression is abundant on naive T-cells and subsets of other immune cells like B cells. Researchers frequently use CD45RA antibodies including CD45RA-PE and CD45RA-FITC for flow cytometry to identify and study immune cell subsets.
Biological function summary

CD45RA plays a significant role in regulating T-cell receptor (TCR) signaling. By dephosphorylating specific phosphotyrosine residues on substrates CD45RA modulates signal transduction pathways important for T-cell activation and differentiation. This protein does not act alone but is part of a regulatory network that influences immune responses and cellular development through its interaction with other cell surface receptors and intracellular kinases.

Pathways

CD45RA modulation is integral to T-cell development and activation processes. It is an important participant in the T-cell receptor signaling pathway and the Jak-STAT signaling pathway. In these pathways CD45 interacts with proteins such as Lck and Fyn which are essential for propagating receptor-mediated signaling events in T-cells. Effective signal regulation through CD45RA is necessary to ensure appropriate immune responses.

CD45RA has links to autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. The aberrant expression or function of CD45RA on immune cells can lead to improper immune activation or suppression contributing to the pathology of these diseases. Crossover with other proteins such as CD45RO which is an isoform involved in memory T-cell function indicates a broader network of immune regulation where CD45RA maintains the balance between immune activation and tolerance.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed : 35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
See full target information PTPRC
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of 109:2491-6 PubMed22308361

2012

Origins of tumor-associated macrophages and neutrophils.

Applications

Flow Cyt

Species

Human

Virna Cortez-Retamozo,Martin Etzrodt,Andita Newton,Philipp J Rauch,Aleksey Chudnovskiy,Cedric Berger,Russell J H Ryan,Yoshiko Iwamoto,Brett Marinelli,Rostic Gorbatov,Reza Forghani,Tatiana I Novobrantseva,Victor Koteliansky,Jose-Luiz Figueiredo,John W Chen,Daniel G Anderson,Matthias Nahrendorf,Filip K Swirski,Ralph Weissleder,Mikael J Pittet

Folia biologica 35:289-97 PubMed2534480

1989

Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102.

Applications

Unspecified application

Species

Unspecified reactive species

V Bazil,I Stefanová,I Hilgert,H Kristofová,S Vanĕk,A Bukovský,V Horejsí

Immunogenetics 29:202-5 PubMed2466778

1989

Sialic acid-dependent epitopes of CD45 molecules of restricted cellular expression.

Applications

Unspecified application

Species

Unspecified reactive species

V Bazil,I Hilgert,H Kristofová,D Maurer,V Horejsí
View all publications
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