FITC荧光Anti-CD45.1抗体[A20] (ab24917)
Key features and details
- FITC Mouse monoclonal [A20] to CD45.1
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2a
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-CD45.1抗体[A20]
参阅全部 CD45.1 一抗 -
描述
FITC荧光小鼠单克隆抗体[A20] to CD45.1 -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
This antibody recognizes all mouse leukocytes expressing the CD45.1 allotype. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to CD45.1. SJL mouse thymocytes and splenocytes
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常规说明
This antibody is useful as a marker for origin of donor and host cells.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.87% Sodium chloride, 0.1% Gelatin, 0.14% Monobasic dihydrogen sodium phosphate -
Concentration information loading... -
纯度
Affinity purified -
Primary antibody说明
This antibody is useful as a marker for origin of donor and host cells. -
克隆
单克隆 -
克隆编号
A20 -
同种型
IgG2a -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab24917于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. |
靶标
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相关性
CD45 is an essential regulator of leukocyte activation and development, and is now known to be a protein tyrosine phosphatase, e.g. CD45 is able to dephosphorylate the Src family of protein kinases. This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants and as allelic forms CD45.1/Ly5.1 and CD45.2/Ly5.2. The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies in which resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. -
细胞定位
Type I membrane protein. -
数据库链接
- Entrez Gene: 19264 Mouse
- SwissProt: P06800 Mouse
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别名
- B220 antibody
- CD45 antibody
- CD45 antigen antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab24917 被引用在 3 文献中.
- Zeng SL et al. Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Mol Med Rep 12:2511-20 (2015). Mouse . PubMed: 25936350
- Salmond RJ et al. The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals. Nat Immunol 15:875-83 (2014). PubMed: 25108421
- Brownlie RJ et al. Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci Signal 5:ra87 (2012). Flow Cyt ; Mouse . PubMed: 23193160