AB18272

FITC Anti-CD15 抗体 [MEM-158]

Name: FITC Anti-CD15抗体[MEM-158] (ab18272)| Abcam中文官网
Brand: Abcam Limited
SKU: AB18272
Price: 5035 CNY
Availability: InStock
Rating: 5 (2 reviews)

FITC Anti-CD15 antibody [MEM-158]

(2 Reviews)

(2 Publications)

Mouse Monoclonal CD15 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing CD15 protein.

2 Images

Flow Cytometry - FITC Anti-CD15 antibody [MEM-158] (AB18272)

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD15 antibody [MEM-158] (AB18272)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab18272 (20 μl reagent / 100 μl of peripheral whole blood).

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD15 antibody [MEM-158] (AB18272)

Separation of human neutrophil granulocytes (red-filled) from CD15 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using ab18272 (20 μl reagent / 100 μl of peripheral whole blood).

不同偶联物与剂型 (4)

Unconjugated

Anti-CD15 antibody [MEM-158]
Biotin

Biotin Anti-CD15 antibody [MEM-158]
695 PerCP/Cy5.5®

PerCP/Cy5.5® Anti-CD15 antibody [MEM-158]
660 APC

APC Anti-CD15 antibody [MEM-158]

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

MEM-158

亚型

IgM

轻链类型

kappa

偶联物

FITC

激发波长/发射波长

Ex: 495nm, Em: 519nm

不含载体蛋白

反应种属

Human

应用

Flow Cyt

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "20 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>Use 20 μl reagent / 100 μl of whole blood or 10^6 cells in a suspension.</p><p><a href='/products/unavailable/fitc-mouse-igm-b117-isotype-control-ab91546'>ab91546</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>" } } }

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性能和储存信息

形式

Liquid

纯化说明

Purified by precipitation and chromatography

存储溶液

pH: 8 Preservative: 0.097% Sodium azide Constituents: BSA, PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD15 also known as Lewis x or 3-fucosyl-N-acetyllactosamine is a carbohydrate antigen with a molecular mass typically not individually defined due to its nature as a glycan. CD15 is expressed on the surface of many human cells including neutrophils and various epithelial cells. It is commonly associated with granulocytes and is used as a cell surface marker. The presence of CD15 can be identified using CD15 antibodies through techniques such as CD15 flow cytometry and CD15 APC labeling.

Biological function summary

CD15 is important in cell-cell interaction mechanisms. It plays a role in mediating adhesion processes particularly in immune responses where it aids neutrophils in adhering to vascular endothelium and transmigrating to sites of infection or inflammation. As a glycoconjugate CD15 forms part of a larger glycoprotein complex on the cell surface interacting with other proteins to facilitate cellular responses and movement.

Pathways

CD15's function as an adhesion molecule ties into key cellular processes such as the selectin pathway. In this pathway it interacts with proteins like E-selectin and L-selectin contributing to leukocyte rolling and extravasation during the immune response. Additionally CD15 is implicated in the signaling pathways that mediate inflammatory responses where its role in neutrophil dynamics is important.

CD15 has notable implications in Hodgkin's lymphoma and certain myeloid leukemias. It is frequently used as a diagnostic marker in these conditions where its overexpression or abnormal expression patterns may signify disease presence or progression. CD15's interaction with other proteins such as CD30 in Hodgkin's lymphoma highlights its utility in understanding the pathological mechanisms and potential therapeutic targets of these disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information CD15

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 16:146 PubMed40128761

2025

Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jianping Wen,Xia Wu,Zhicheng Shu,Dongxu Wu,Zonghua Yin,Minglong Chen,Kun Luo,Kebo Liu,Yulong Shen,Yi Le,Qingxia Shu

Journal of the neurological sciences 346:164-73 PubMed25175854

2014

Thyroid hormone-dependent epigenetic suppression of herpes simplex virus-1 gene expression and viral replication in differentiated neuroendocrine cells.

Applications

Unspecified application

Species

Unspecified reactive species

Robert W Figliozzi,Feng Chen,Matthew Balish,Amakoe Ajavon,S Victor Hsia

View all publications

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FITC Anti-CD15 抗体 [MEM-158]