FITC荧光Anti-CD11b抗体[M1/70] (ab24874)
![Flow Cytometry - FITC Anti-CD11b antibody [M1/70] (ab24874)](https://www.abcam.cn/ps/products/24/ab24874/Images/ab24874-456671-fitc-anti-cd11b-antibody-m1-70-flow-cytometry-bone-marrow-c57bl-6-mouse.jpg "Flow Cytometry - FITC Anti-CD11b antibody [M1/70] (ab24874)")
Key features and details
- FITC Rat monoclonal [M1/70] to CD11b
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2b
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-CD11b抗体[M1/70]
参阅全部 CD11b 一抗 -
描述
FITC荧光大鼠单克隆抗体[M1/70] to CD11b -
宿主
Rat -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
Alpha M subunit (Mr 170 kDa) of the CD11b/CD18 heterodimer. -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse
预测可用于: Human
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免疫原
Tissue/ cell preparation (Mouse): C57BL/10 mouse splenic T cells and concanavaline A-activated C57BL/10 splenocytes.
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阳性对照
- Flow Cyt: Mouse C57BL/6 bone marrow cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Do Not Freeze. Store undiluted. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.14% Monobasic dihydrogen sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin -
Concentration information loading... -
纯度
Affinity purified -
克隆
单克隆 -
克隆编号
M1/70 -
同种型
IgG2b -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
- Alexa Fluor® 488 Anti-CD11b antibody [M1/70] (ab197701)
- Alexa Fluor® 647 Anti-CD11b antibody [M1/70] (ab197702)
- PerCP/Cy5.5® Anti-CD11b antibody [M1/70] (ab210299)
- PE/Cy7® Anti-CD11b antibody [M1/70] (ab218786)
- violetFluor™ 450 Anti-CD11b antibody [M1/70] (ab242266)
- PE Anti-CD11b antibody [M1/70] (ab25175)
- redFluor™ 710 Anti-CD11b antibody [M1/70] (ab253091)
- APC Anti-CD11b antibody [M1/70] (ab25482)
- PE/Cy5® Anti-CD11b antibody [M1/70] (ab25533)
- APC/Cy7® Anti-CD11b antibody [M1/70] (ab79096)
- Anti-CD11b antibody [M1/70] (ab8878)
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab24874于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt | (1) |
Use at an assay dependent concentration.
ab136125 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. ab136125 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. -
组织特异性
Predominantly expressed in monocytes and granulocytes. -
疾病相关
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
结构域
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3684 Human
- Entrez Gene: 16409 Mouse
- Omim: 120980 Human
- SwissProt: P11215 Human
- SwissProt: P05555 Mouse
- Unigene: 172631 Human
- Unigene: 262106 Mouse
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别名
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
see all
图片
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Flow Cytometry - FITC Anti-CD11b antibody [M1/70] (ab24874)
Flow Cytometry analysis of Mouse C57BL/6 bone marrow cells labeling CD11b with ab24874 at 0.5µg (solid line), Rat IgG2b (FITC) isotype control (dashed line) at 0.5µg concentration.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (17)
ab24874 被引用在 17 文献中.
- Qin H et al. Low-intensity pulsed ultrasound promotes skeletal muscle regeneration via modulating the inflammatory immune microenvironment. Int J Biol Sci 19:1123-1145 (2023). PubMed: 36923940
- Wang L et al. miR-4780 Derived from N2-Like Neutrophil Exosome Aggravates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer. Stem Cells Int 2023:2759679 (2023). PubMed: 37576407
- Chen Y et al. Cocktail of isobavachalcone and curcumin enhance eradication of Staphylococcus aureus biofilm from orthopedic implants by gentamicin and alleviate inflammatory osteolysis. Front Microbiol 13:958132 (2022). PubMed: 36212814
- Chen B et al. M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis. Oxid Med Cell Longev 2021:9959746 (2021). PubMed: 34745428
- Meng Q et al. Human bone marrow mesenchymal stem cell-derived extracellular vesicles impede the progression of cervical cancer via the miR-144-3p/CEP55 pathway. J Cell Mol Med 25:1867-1883 (2021). PubMed: 33417281