FITC荧光Anti-CD105抗体[MEM-229] (ab53318)
![Immunohistochemistry (Frozen sections) - FITC Anti-CD105 antibody [MEM-229] (ab53318)](https://www.abcam.cn/ps/products/53/ab53318/Images/ab53318-66100-anti-cd105-antibody-mem-229-fitc-immunohistochemistry.jpg "Immunohistochemistry (Frozen sections) - FITC Anti-CD105 antibody [MEM-229] (ab53318)")
Key features and details
- FITC Mouse monoclonal [MEM-229] to CD105
- Suitable for: IHC-Fr
- Reacts with: Pig
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2a
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-CD105抗体[MEM-229]
参阅全部 CD105 一抗 -
描述
FITC荧光小鼠单克隆抗体[MEM-229] to CD105 -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
The antibody MEM-229 recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B
lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. -
经测试应用
适用于: IHC-Frmore details -
种属反应性
与反应: Pig -
免疫原
Tissue, cells or virus corresponding to Human CD105.
Database link: P17813 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.2% BSA, PBS -
Concentration information loading... -
纯度
Size exclusion -
纯化说明
Purified by size-exclusion chromatography. -
克隆
单克隆 -
克隆编号
MEM-229 -
同种型
IgG2a -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab53318于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
1/200. Fix with acetone.
|
| 说明 |
|---|
|
IHC-Fr
1/200. Fix with acetone. |
靶标
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功能
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. -
组织特异性
Endoglin is restricted to endothelial cells in all tissues except bone marrow. -
疾病相关
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity. -
细胞定位
Membrane. - Information by UniProt
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别名
- AI528660 antibody
- AI662476 antibody
- CD 105 antibody
see all
图片
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Immunohistochemistry (Frozen sections) - FITC Anti-CD105 antibody [MEM-229] (ab53318)ab53318 staining CD105 in infarcted porcine heart by Immunohistochemistry (Frozen sections). Cell nuclei were counterstained blue with DAPI.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (22)
ab53318 被引用在 22 文献中.
- Noh S et al. Selective Extracellular Matrix Guided Mesenchymal Stem Cell Self-Aggregate Engineering for Replication of Meniscal Zonal Tissue Gradient in a Porcine Meniscectomy Model. Adv Healthc Mater 12:e2301180 (2023). PubMed: 37463568
- Bernardini C et al. Isolation of Vascular Wall Mesenchymal Stem Cells from the Thoracic Aorta of Adult Göttingen Minipigs: A New Protocol for the Simultaneous Endothelial Cell Collection. Animals (Basel) 13:N/A (2023). PubMed: 37627392
- Oh J et al. Mesenchymal stem cells genetically engineered to express platelet-derived growth factor and heme oxygenase-1 ameliorate osteoarthritis in a canine model. J Orthop Surg Res 16:43 (2021). PubMed: 33430899
- Chen Y et al. MSC-Secreted Exosomal H19 Promotes Trophoblast Cell Invasion and Migration by Downregulating let-7b and Upregulating FOXO1. Mol Ther Nucleic Acids 19:1237-1249 (2020). PubMed: 32069774
- Meng Q & Qiu B Exosomal MicroRNA-320a Derived From Mesenchymal Stem Cells Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Activation by Suppressing CXCL9 Expression. Front Physiol 11:441 (2020). PubMed: 32528301