FITC荧光Anti-C4c+C4b抗体(ab4216)
Key features and details
- FITC Rabbit polyclonal to C4c+C4b
- Suitable for: IHC-P
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
概述
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产品名称
FITC荧光Anti-C4c+C4b抗体 -
描述
FITC荧光兔多克隆抗体to C4c+C4b -
宿主
Rabbit -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
The details of the immunogen for this antibody are not available.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.3
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
纯度
IgG fraction -
纯化说明
Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
靶标
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相关性
C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. -
细胞定位
Secreted -
数据库链接
- Entrez Gene: 720 Human
- Entrez Gene: 721 Human
- SwissProt: P0C0L4 Human
- SwissProt: P0C0L5 Human
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别名
- Acidic complement C4 antibody
- Basic complement C4 antibody
- CH antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FITC Anti-C4c+C4b antibody (ab4216)
Immunohistochemistry (Formalin fixed paraffin-embedded sections) analysis of human kidney stained labelling C4C Complement with ab4216.
数据表及文件
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Datasheet download
文献 (1)
ab4216 被引用在 1 文献中.
- Ispasanie E et al. Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations. Virulence 9:1138-1149 (2018). PubMed: 30067453
