AB108616

重组Anti-Fibrinogen alpha chain抗体[EPR2918]

Anti-Fibrinogen alpha chain antibody [EPR2918]

RabMAb
Recombinant
了解详情

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(5 Publications)

Rabbit Recombinant Monoclonal Fibrinogen alpha chain antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.

查看别名

Fibrinogen alpha chain, FGA

2 Images

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Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (AB108616)

Blocking and diluting buffer : 5% NFDM/TBST

All lanes:

Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (ab108616) at 0.9 µg/mL

All lanes:

Human plasma lysates at 15 µg

Secondary

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Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Predicted band size: 95 kDa

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Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (AB108616)

All lanes:

Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (ab108616) at 1/2000 dilution

Lane 1:

Human plasma lysates at 10 µg

Lane 2:

Human fetal liver lysates at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 95 kDa

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不同偶联物与剂型 (1)

Carrier free

Anti-Fibrinogen alpha chain antibody [EPR2918] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR2918

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

The immunogen is derived from isoform alpha-E, UniProt accession P02671-1, and the antibody is not expected to detect isoform alpha.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

储存信息

Stable for 12 months at -20°C

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

See full target information FGA

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

European journal of medical research 30:859 PubMed41013641

2025

RHBDD1 induces cell cycle arrest in TP53-mutant NSCLC cells by promoting endoplasmic reticulum-associated degradation of p53 and DNA-PKcs.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Chen,Yang Wang,Shuai Shen,Libin Zhang,Jun Liu,Xiangyun Yan,Hao Peng,Zheyuan Xu

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 22:e00538 PubMed39904669

2025

Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Huanzhu Liu,Ruoyang Yu,Muwei Zhang,Xiaoyan Zheng,Lizi Zhong,Wanlin Yang,Yuqi Luo,Zifeng Huang,Jialing Zheng,Hui Zhong,Xiaobo Wei,Wenhua Zheng,Yinghua Yu,Qing Wang

Frontiers in genetics 11:551065 PubMed33424913

2020

Integration of Transcriptome Resequencing and Quantitative Proteomics Analyses of Collagenase VII-Induced Intracerebral Hemorrhage in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Cao,Yu Guo,Qiang Zhang,Yinchun Fan,Qian Liu,Jiancheng Song,Hua Zhong,Shengtao Yao

Proteomics. Clinical applications 14:e1900099 PubMed32677377

2020

Isoform 1 of Fibrinogen Alpha Chain Precursor is a Potential Biomarker for Steroid-Induced Osteonecrosis of the Femoral Head.

Applications

Unspecified application

Species

Unspecified reactive species

Liying Liu,Jidong Song,Jun Li,Na Huang,Juan Yang,Shugang Hu,Rui Ma,Wei Wang

Blood advances 4:2939-2949 PubMed32603423

2020

Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer.

Applications

Unspecified application

Species

Unspecified reactive species

Lorena Buitrago,Hina Zafar,Yixiao Zhang,Jihong Li,Thomas Walz,Barry S Coller

View all publications

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Abcam Product Promise

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详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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重组Anti-Fibrinogen alpha chain抗体[EPR2918]