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Anti-Fibrillin 2抗体(ab128026)

Submit a review Q&A (1)References (3)

Key features and details

  • Rabbit polyclonal to Fibrillin 2
  • Suitable for: ELISA, IHC-P, ICC, IP, WB
  • Reacts with: Human
  • Isotype: IgG

概述

  • 产品名称

    Anti-Fibrillin 2抗体
    参阅全部 Fibrillin 2 一抗

  • 描述

    兔多克隆抗体to Fibrillin 2

  • 宿主

    Rabbit

  • 特异性

    No cross-reactivity with Fibrillin 1.

  • 经测试应用

    适用于: ELISA, IHC-P, ICC, IP, WBmore details

  • 种属反应性

    与反应: Human
    预测可用于: Cow

  • 免疫原

    Recombinant fragment containing glycine-rich domain of exon 10 of Human Fibrillin 2.

  • 阳性对照

    • Human Prostate, Extra Cellular tissue

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab128026于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
ELISA
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
ICC
Use at an assay dependent concentration.
IP
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration.
说明
ELISA
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
ICC
Use at an assay dependent concentration.
IP
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration.

靶标

  • 功能

    Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

  • 疾病相关

    Defects in FBN2 are the cause of congenital contractural arachnodactyly (CCA) [MIM:121050]; also known as Beals syndrome or distal arthrogryposis type 9 (DA9). CCA is a rare, autosomal dominant connective tissue disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears. Phenotypically similar to Marfan syndrome, CCA does not affect the aorta and the eyes.

  • 序列相似性

    Belongs to the fibrillin family.
    Contains 47 EGF-like domains.
    Contains 9 TB (TGF-beta binding) domains.

  • 细胞定位

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

  • 数据库链接

    • 别名

      • CCA antibody
      • congenital contractural arachnodactyly (Marfanoid-like) antibody
      • DA9 antibody
      • FBN2 antibody
      • FBN2_HUMAN antibody
      • fibrillin 2 (congenital contractural arachnodactyly) antibody
      • Fibrillin-2 antibody
      see all

    文献 (3)

    发表研究结果有使用 ab128026？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab128026 被引用在 3 文献中.

    • Williams JL  et al. Defining the molecular signatures of human right heart failure. Life Sci 196:118-126 (2018). PubMed: 29366750
    • Villain G  et al. MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations. FEBS J 285:4394-4412 (2018). PubMed: 30338930
    • Gilpin SE  et al. Fibrillin-2 and Tenascin-C bridge the age gap in lung epithelial regeneration. Biomaterials 140:212-219 (2017). PubMed: 28662401

    客户评价及客户问答

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    Question

    Would like to test ab128026 and ab54778 with bovine samples

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    Answer

    DISCOUNT CODE: XXXXXXX

    DISCOUNT CODE: XXXXXXX

    Expiration date: 30-05-2013

    Value: £235 each

    I am very pleased to hear you would like to accept our offer and test ab54778 and ab128026 in Bovine. This code will give you £235 x 2 off your next order before the expiration date. To redeem this offer, please submit an Abreview for Bovine and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. Please remember that submission of the Abreview is sufficient for the discount code to become active.
    For more information on how to submit an Abreview, please visit the site: https://www.abcam.com/Abreviews.

    The terms and conditions applicable to this offer can be found here: www.abcam.com/abtrial.

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com