Anti-FGFR4抗体(ab119378)
Key features and details
- Rabbit polyclonal to FGFR4
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
-
产品名称
Anti-FGFR4抗体
参阅全部 FGFR4 一抗 -
描述
兔多克隆抗体to FGFR4 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat -
免疫原
Synthetic peptide conjugated to KLH, surrounding amino acids 45-49 (L-T-V-A-L) of Human FGFR4.
-
阳性对照
- Rat liver and brain tissues.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 48% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
without Mg2+ and Ca2+ -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab119378于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/1000. Detects a band of approximately 110 kDa (predicted molecular weight: 88 kDa).
|
| 说明 |
|---|
|
WB
1/500 - 1/1000. Detects a band of approximately 110 kDa (predicted molecular weight: 88 kDa). |
靶标
-
功能
Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19. -
组织特异性
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
翻译后修饰
Glycosylated.
Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization. -
细胞定位
Membrane. Isoform 2 may be secreted. - Information by UniProt
-
数据库链接
- Entrez Gene: 25114 Rat
- SwissProt: Q498D6 Rat
- Unigene: 24104 Rat
-
别名
- CD 334 antibody
- CD334 antibody
- CD334 antigen antibody
see all
图片
-
Western blot - Anti-FGFR4 antibody (ab119378)All lanes : Anti-FGFR4 antibody (ab119378) at 1/500 dilution
Lane 1 : Rat liver lysate
Lane 2 : Rat brain lysate
Predicted band size: 88 kDa
Observed band size: 110 kDa why is the actual band size different from the predicted?
数据表及文件
-
SDS download
-
Datasheet download
文献 (7)
ab119378 被引用在 7 文献中.
- Li H et al. Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo. Front Pharmacol 14:1148737 (2023). PubMed: 37077819
- Kishimoto H et al. Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway. Front Cardiovasc Med 10:990422 (2023). PubMed: 36895836
- Chen RA et al. Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition. mSystems 7:e0017222 (2022). PubMed: 35670534
- Li H et al. Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis. Nutr Metab (Lond) 17:34 (2020). PubMed: 32377219
- Lee KW et al. FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPAR? regulators. FEBS Open Bio 9:769-780 (2019). PubMed: 30984550
- Erstad DJ et al. Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP-305, a novel farnesoid X receptor agonist. Hepatol Commun 2:821-835 (2018). PubMed: 30027140
- Romain G et al. Enterohepatic bacterial infections dysregulate the FGF15-FGFR4 endocrine axis. BMC Microbiol 13:238 (2013). WB ; Mouse . PubMed: 24165751