AB215353

Anti-FGFBP1抗体

Name: FGFBP1抗体 (ab215353)| Abcam中文官网
Brand: Abcam Limited
SKU: AB215353
Price: 4606 CNY
Availability: InStock

Anti-FGFBP1 antibody

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(3 Publications)

Rabbit Polyclonal FGFBP1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FGFBP1.

查看别名

FGFBP, HBP17, FGFBP1, Fibroblast growth factor-binding protein 1, FGF-BP, FGF-BP1, FGF-binding protein 1, FGFBP-1, 17 kDa heparin-binding growth factor-binding protein, 17 kDa HBGF-binding protein, HBp17

1 Images

Supplier Data

Western blot - Anti-FGFBP1 antibody (AB215353)

Gel : 12%SDS-PAGE

All lanes:

Western blot - Anti-FGFBP1 antibody (ab215353) at 1/350 dilution

All lanes:

A549 cell lysate at 40 µg

Secondary

All lanes:

Goat anti rabbit IgG at 1/8000 dilution

Predicted band size: 26 kDa

true

Exposure time: 1min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human FGFBP1. The exact immunogen used to generate this antibody is proprietary information.

Q14512

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/350 - 1/2000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FGFBP1 also known as fibroblast growth factor binding protein 1 is an extracellular regulatory protein that mechanically binds fibroblast growth factors (FGFs). This protein has a molecular mass of approximately 30 kilodaltons. FGFBP1 is expressed in various tissues including the skin liver and kidney. It acts as a carrier enhancing the bioavailability of FGFs by releasing them from the extracellular matrix or cell surfaces facilitating their interaction with FGF receptors.

Biological function summary

FGFBP1 plays a significant role in modulating FGF signaling influencing processes such as angiogenesis wound healing and tissue repair. It acts in conjunction with other FGFs to form a complex that is essential for efficient signal transduction across cellular membranes. By interacting with FGFs FGFBP1 impacts cell proliferation and differentiation particularly in epithelial and endothelial cells.

Pathways

FGFBP1 is a critical component of the FGF signaling pathway and has a role in pathways related to cell growth and tissue development. It works alongside other proteins such as FGF1 and FGF2 to regulate developmental processes. The interaction of FGFBP1 in the signaling pathway ensures the proper function and maintenance of cellular activities aligning with processes like angiogenesis and morphogenesis.

FGFBP1 has connections to cancer and chronic inflammatory diseases such as psoriasis. In cancer FGFBP1's role in promoting FGF-mediated angiogenesis supports tumor growth and metastasis especially in collaboration with other FGFs like FGF2. In chronic inflammatory disorders dysregulation of FGFBP1 can lead to aberrant FGF signaling contributing to excessive tissue inflammation and impaired healing. This highlights its potential as a target for therapeutic intervention in these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

See full target information FGFBP1

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Medical oncology (Northwood, London, England) 41:17 PubMed38087142

2023

KLF5 promotes esophageal squamous cell cancer through the transcriptional activation of FGFBP1.

Applications

Unspecified application

Species

Unspecified reactive species

Fengyun Wang,Ming Luo,Yufeng Cheng

FEBS open bio : PubMed33529461

2021

BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF-BP1.

Applications

Unspecified application

Species

Unspecified reactive species

Fengyun Wang,Ming Luo,Honglan Qu,Yufeng Cheng

Oncology letters 16:809-814 PubMed29963148

2018

FGFRL1 deficiency reduces motility and tumorigenic potential of cells derived from oesophageal squamous cell carcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshinori Takei,Takafumi Matsumura,Kazuaki Watanabe,Hirokazu Nakamine,Tetsuo Sudo,Kazuharu Shimizu,Yutaka Shimada

View all publications

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Anti-FGFBP1抗体

Anti-FGFBP1 antibody

Western blot - Anti-FGFBP1 antibody (AB215353)