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AB209991

Anti-FGF8 抗体

Anti-FGF8 antibody

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(1 Publication)

Rabbit Polyclonal FGF8A antibody. Suitable for IHC - Wmt and reacts with Zebrafish samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Zebrafish fgf8a aa 50 to C-terminus.

查看别名

fgf-8, fgf8, Fibroblast growth factor 8, FGF-8

1 Images
IHC - Wholemount - Anti-FGF8 antibody (AB209991)
  • IHC - Wmt

Supplier Data

IHC - Wholemount - Anti-FGF8 antibody (AB209991)

Whole mount Immunohistochemical analysis of paraformaldehyde-fixed Zebrafish embryos labeling FGF8 with ab209991 at 1/200 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Zebrafish

应用

IHC - Wmt

applications

免疫原

Recombinant Fragment Protein within Zebrafish fgf8a aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O57341

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替代产品

Primary Antibodies

AB81384

Anti-FGF8 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF8 antibody (AB81384)

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  • 1
Primary Antibodies

AB89550

Anti-FGF8 antibody [MM0291-8D24]

Western blot - Anti-FGF8 antibody [MM0291-8D24] (AB89550)

  • 5
  • 1

搭配使用产品

Primary Antibodies

AB209836

Anti-PAX6 antibody

IHC - Wholemount - Anti-PAX6 antibody (AB209836)

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  • 0
Primary Antibodies

AB229318

Anti-Pax2 antibody

IHC - Wholemount - Anti-Pax2 antibody (AB229318)

  • 5
  • 1
Primary Antibodies

AB211129

Anti-MTMR2 antibody

IHC - Wholemount - Anti-MTMR2 antibody (AB211129)

  • 0
  • 0
Primary Antibodies

AB223760

Anti-TBX5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBX5 antibody (AB223760)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCWmt" : {"fullname" : "IHC - Wholemount", "shortname":"IHC - Wmt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCWmt-species-checked": "testedAndGuaranteed", "IHCWmt-species-dilution-info": "1/100 - 1/500", "IHCWmt-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The FGF8 protein also known as fibroblast growth factor 8 plays a mechanical role in cell signaling and development. The FGF8 gene encodes two main isoforms: FGF8a and FGF8b each with different biological activities. FGF8 has a molecular mass of approximately 22-24 kDa. It expresses in developing tissues particularly in the embryo during early stages of vertebrate development. FGF8 interacts with fibroblast growth factor receptors (FGFRs) to initiate a cascade of signaling events leading to cellular responses.
Biological function summary

The FGF8 protein influences the regulation of cell division growth and differentiation particularly in embryonic development. FGF8 an integral part of several signaling complexes activates pathways that guide mesoderm and neural plate induction. Its expression is essential for limb and brain development providing necessary signaling cues required for proper patterning and morphogenetic processes.

Pathways

The FGF8 protein plays a central role in the MAPK/ERK signaling and PI3K/AKT pathways important mechanisms that govern cellular proliferation and survival. These pathways involve several proteins such as FGFR1 and FGFR2 which interact with FGF8 to mediate its effects. Through these pathways FGF8 coordinates with other members of the fibroblast growth factor family to regulate cellular functions in a concerted manner.

The FGF8 protein associates with various congenital malformations specifically conditions like Kallmann syndrome and certain craniofacial dysplasias. Mutations or dysregulation in FGF8 can disrupt normal signaling processes leading to abnormalities in development. The protein closely interacts with other growth factors and receptors such as FGFR1 which when altered might contribute to the pathogenesis of these disorders by affecting the signaling pathways they share with FGF8.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis (PubMed : 19164561).
See full target information fgf8a
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 49:13108-13121 PubMed34878141

2021

FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Wenlu Fan,Xiaoye Jin,Man Xu,Yongmei Xi,Weiguo Lu,Xiaohang Yang,Min-Xin Guan,Wanzhong Ge
View all publications
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