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AB168743

Anti-FGF5抗体

Anti-FGF5 antibody

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(2 Publications)

Mouse Polyclonal FGF5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF5.

查看别名

Fibroblast growth factor 5, FGF-5, Heparin-binding growth factor 5, Smag-82, HBGF-5, FGF5

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-FGF5 antibody (AB168743)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FGF5 antibody (AB168743)

Immunofluorescence analysis of HeLa cells labelling FGF5 with ab168743 at 10 ug/ml.

Western blot - Anti-FGF5 antibody (AB168743)
  • WB

Unknown

Western blot - Anti-FGF5 antibody (AB168743)

All lanes:

Western blot - Anti-FGF5 antibody (ab168743) at 1 µg/mL

Lane 1:

FGF5 transfected 293T cell lysate (13.53 KDa) at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugated secondary antibody at 1/2500 dilution

Predicted band size: 29 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human FGF5.

P12034

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Lyophilized
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FGF5 also known as fibroblast growth factor 5 is a protein involved in various cellular processes with a molecular mass of approximately 29 kDa. It is part of the FGF family which includes at least 22 members playing roles in cell growth differentiation and regulation. FGF5 expression occurs mainly in hair follicles skeletal muscles and the central nervous system. The protein has been identified in epithelial cells and the stromal compartment surrounding hair follicles.
Biological function summary

FGF5 functions as a signaling molecule that influences hair growth cycle regulation. It is an important player in the transition of hair follicles from the anagen (growth) phase to the catagen (regression) phase. FGF5 does not act alone but interacts with various cellular receptors particularly FGFR1 and FGFR2 which facilitate its role in hair cycle modulation. It is not typically part of a stable multi-protein complex but works as a soluble factor influencing nearby cell behavior.

Pathways

FGF5 engages with signaling cascades such as the MAPK/ERK pathway and the PI3K/AKT pathway which are significant for cell proliferation and survival. FGF5 can modulate these pathways by binding to FGFR1 and FGFR2 receptors leading to downstream signaling that affects cell behavior. These pathways illustrate its involvement with several other FGF family members such as FGF7 and FGF10 showcasing a broad effect on cellular dynamics and development.

FGF5 has been linked to conditions such as congenital hypotrichosis and alopecia where abnormalities in hair growth cycles occur. Dysfunctions in FGF5 signaling can lead to prolonged anagen phases or premature catagen transitions. Additionally FGF5 has connections to cancer development due to its role in cell proliferation and differentiation; aberrations in FGF5 activity can contribute to tumorigenesis. Although not directly linked proteins like FGFR1 can mediate these effects increasing the complexity of its involvement in disease progression.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).
See full target information FGF5
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of pharmaceutical analysis 13:894-907 PubMed37719196

2023

Single-cell and spatial heterogeneity landscapes of mature epicardial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jianlin Du,Xin Yuan,Haijun Deng,Rongzhong Huang,Bin Liu,Tianhua Xiong,Xianglin Long,Ling Zhang,Yingrui Li,Qiang She

Cell transplantation 29:963689720963936 PubMed33028108

2020

Clarification of the Role of miR-9 in the Angiogenesis, Migration, and Autophagy of Endothelial Progenitor Cells Through RNA Sequence Analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Zhu,Li-Li Sun,Wen-Dong Li,Xiao-Qiang Li
View all publications
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