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AB169748

Anti-FGF1 alpha抗体

Anti-FGF1 alpha antibody

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(5 Publications)

Mouse Polyclonal FGF1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF1.

查看别名

FGFA, FGF1, Fibroblast growth factor 1, FGF-1, Acidic fibroblast growth factor, Endothelial cell growth factor, Heparin-binding growth factor 1, aFGF, ECGF, HBGF-1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-FGF1 alpha antibody (AB169748)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FGF1 alpha antibody (AB169748)

Immunocytochemistry/Immunofluorescence analysis of HeLa cells labeling FGF1 alpha with ab169748 at 10μg/ml.

Western blot - Anti-FGF1 alpha antibody (AB169748)
  • WB

Supplier Data

Western blot - Anti-FGF1 alpha antibody (AB169748)

All lanes:

Western blot - Anti-FGF1 alpha antibody (ab169748) at 1 µg/mL

Lane 1:

FGF1 alpha transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 17 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human FGF1.

P05230

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Sheep": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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为什么推荐这个？

我们推荐这个产品，因为它经常被用于相同的实验或相关的研究。

我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Constituents: 100% PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FGF1 alpha also known as fibroblast growth factor 1 or aFGF functions as an important mediator in cellular processes such as proliferation differentiation and angiogenesis. This protein with a mass of approximately 18 kDa binds to specific fibroblast growth factor receptors (FGFRs) and heparan sulfate proteoglycans to initiate signal transduction. FGF1 alpha expresses in various tissues including brain liver and heart and plays significant roles in development and tissue repair.
Biological function summary

FGF1 alpha facilitates critical cellular functions by promoting cellular growth and survival. It often associates with other members of the fibroblast growth factor family and signaling molecules to form complexes essential for signal cascade initiation. This protein supports cellular resilience under stress conditions and participates in a variety of cellular activities which include wound healing and neovascularization.

Pathways

FGF1 alpha plays a significant role in the MAPK/ERK and PI3K/Akt signaling pathways. These pathways are fundamental for regulating cell cycle progression apoptosis and metabolic stability. FGF1 alpha interacts with proteins like FGF2 and FGFR1 which are involved in transmitting signals from the cell membrane to the nucleus impacting gene expression and cellular response.

FGF1 alpha is associated with cancer and metabolic disorders such as obesity-related insulin resistance. Its dysregulation or aberrant expression may result in uncontrolled cell growth typical of tumorigenic processes. FGF1 alpha often relates to FGF2 in oncogenic pathways where both proteins contribute to angiogenesis and tumor growth indicating their potential targets in therapeutic strategies for cancer treatment.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV : ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed : 18441324, PubMed : 20422052). Can induce angiogenesis (PubMed : 23469107).
See full target information FGF1
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:344 PubMed36670126

2023

Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Pei,Li Ma,Junjun Jing,Jifan Feng,Yuan Yuan,Tingwei Guo,Xia Han,Thach-Vu Ho,Jie Lei,Jinzhi He,Mingyi Zhang,Jian-Fu Chen,Yang Chai

Frontiers in cell and developmental biology 9:693694 PubMed34195203

2021

Hypoxia Response Element-Directed Expression of aFGF in Neural Stem Cells Promotes the Recovery of Spinal Cord Injury and Attenuates SCI-Induced Apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yibo Ying,Yifan Zhang,Yurong Tu,Min Chen,Zhiyang Huang,Weiyang Ying,Qiuji Wu,Jiahui Ye,Ziyue Xiang,Xiangyang Wang,Zhouguang Wang,Sipin Zhu

Cell death & disease 12:107 PubMed33479232

2021

Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Li,Beini Wang,Chengbiao Wu,Duohui Li,Yanqing Wu,Libing Ye,Luxia Ye,Xiongjian Chen,Peifeng Li,Yuan Yuan,Hongyu Zhang,Ling Xie,Xiaokun Li,Jian Xiao,Jian Wang

Scientific reports 10:2939 PubMed32076044

2020

Activated FGF2 signaling pathway in tumor vasculature is essential for acquired resistance to anti-VEGF therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Kenji Ichikawa,Saori Watanabe Miyano,Yukinori Minoshima,Junji Matsui,Yasuhiro Funahashi

Molecular medicine reports 18:1025-1030 PubMed29845277

2018

Acid fibroblast growth factor facilitates the progression of atherosclerotic plaques regardless of alterations in serum lipid expression levels in HFD‑fed ApoE‑/‑ mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jibo Han,Yao Du,Lintao Wang,Xiong Chen,Liqin Jiang,Jianjiang Xu
View all publications
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