AB197897

重组Anti-FCRL2抗体[EPR16122]

Anti-FCRL2 antibody [EPR16122]

RabMAb
Recombinant
了解详情

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(1 Publication)

Rabbit Recombinant Monoclonal FCRL2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.

查看别名

CD307b, FCRH2, IFGP4, IRTA4, SPAP1, UNQ9236/PRO31998, FCRL2, Fc receptor-like protein 2, FcR-like protein 2, FcRL2, Fc receptor homolog 2, IFGP family protein 4, Immunoglobulin receptor translocation-associated protein 4, SH2 domain-containing phosphatase anchor protein 1, FcRH2

4 Images

Supplier Data

Immunoprecipitation - Anti-FCRL2 antibody [EPR16122] (AB197897)

Immunoprecipitation analysis of 293 (Human epithelial cells from embryonic kidney) whole cell extract labeling FCRL2 using ab197897 at 1/60 dilution (Lane 2).
Lane 3 : IP using Rabbit monoclonal IgG (ab172730) ) instead of ab197897 in 293 (Human epithelial cells from embryonic kidney) whole cell extract.
Lane 1 : Input : 10 μg 293 (Human epithelial cells from embryonic kidney) whole cell extract.
Subsequent WB detection was performed using ab197897 at 1/1000 dilution.
An Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1500 was used as secondary antibody.

All lanes:

Immunoprecipitation - Anti-FCRL2 antibody [EPR16122] (ab197897)

Predicted band size: 56 kDa

false

Supplier Data

Western blot - Anti-FCRL2 antibody [EPR16122] (AB197897)

All lanes:

Western blot - Anti-FCRL2 antibody [EPR16122] (ab197897) at 1/1000 dilution

All lanes:

NAMALWA (human Burkitt's lymphoma ) whole cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 56 kDa

false

Exposure time: 30s

Supplier Data

Western blot - Anti-FCRL2 antibody [EPR16122] (AB197897)

All lanes:

Western blot - Anti-FCRL2 antibody [EPR16122] (ab197897) at 1/1000 dilution

All lanes:

Human tonsil lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 56 kDa

false

Exposure time: 3min

Supplier Data

Western blot - Anti-FCRL2 antibody [EPR16122] (AB197897)

All lanes:

Western blot - Anti-FCRL2 antibody [EPR16122] (ab197897) at 1/1000 dilution

All lanes:

HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 56 kDa

false

Exposure time: 30s

不同偶联物与剂型 (1)

Carrier free

Anti-FCRL2 antibody [EPR16122] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR16122

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IP

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/60", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FCRL2 also known as FC Receptor-like 2 or CD307b belongs to the family of Fc receptor-like molecules. It is a transmembrane receptor with a mass of approximately 110 kDa. FCRL2 shows expression mainly in B cells with higher levels notably in some mature B cell subtypes found in the lymphoid tissues. Its expression is significantly observed in the follicles of the spleen and tonsils indicating a role in the immune responses centered around these tissues.

Biological function summary

FCRL2 modulates signaling in B cells partaking in immune regulation. It participates in the regulatory networks that adjust B-cell function and differentiation but it does not form any known complex with other proteins. The protein has a structural similarity to classical Fc receptors that suggests a modulatory role in immune response. Researchers consider FCRL2 significant in altering B cell receptor signaling though the exact ligands remain under active investigation.

Pathways

The protein FCRL2 integrates into immune signaling pathways such as the B cell receptor (BCR) signaling pathway. This pathway plays a direct role in B cell activation and antibody production. FCRL2 interacts with other FCRLS members in such pathways to maintain immune homeostasis. The extent of its integration implies a fine-tuning of B cell functions and links to Fcγ receptors indicating a shared regulatory network in pathways.

FCRL2 associates with conditions like chronic lymphocytic leukemia (CLL) and autoimmune diseases. Increased expression of FCRL2 often correlates with certain leukemia subtypes hinting at its potential as a biomarker for disease progression. Moreover its dysregulation may contribute to autoimmune conditions where B cell dysfunctions are central. Studies have also connected FCRL2 with other immune-regulatory proteins in these diseases further highlighting its relevance in pathological conditions related to immune response dysregulation.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May have an regulatory role in normal and neoplastic B cell development.

See full target information FCRL2

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Virulence 16:2530164 PubMed40667873

2025

Ferroptosis is important for replication and virulence and .

Applications

Unspecified application

Species

Unspecified reactive species

Ling-Yu Li,Chun-Xue Zhou,Bing Han,Hany M Elsheikha,Hui-Jie Qiu,Xu-Dian An,Ting Zeng,Dai-Ang Liu,Qing Yang,Xing-Quan Zhu,Huai-Yu Zhou

View all publications

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重组Anti-FCRL2抗体[EPR16122]