Anti-FAT4抗体(ab130076)
Key features and details
- Rabbit polyclonal to FAT4
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG
概述
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产品名称
Anti-FAT4抗体 -
描述
兔多克隆抗体to FAT4 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Recombinant fragment -
免疫原
Synthetic peptide conjugated to KLH corresponding to a region within Human FAT4 (SwissProt Q6V0I7).
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阳性对照
- recombinant FAT4 protein
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7
Preservative: 0.05% Sodium azide
Constituents: 74% Tris buffered saline, 25% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab130076于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 543 kDa).
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| 说明 |
|---|
|
WB
1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 543 kDa). |
靶标
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功能
May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules. -
组织特异性
Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. -
序列相似性
Contains 34 cadherin domains.
Contains 6 EGF-like domains.
Contains 2 laminin G-like domains. -
细胞定位
Membrane. In the kidney, localizes to primary cilia. - Information by UniProt
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别名
- Cadherin family member 14 antibody
- Cadherin related family member 11 antibody
- CDHF14 antibody
see all
图片
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Western blot - Anti-FAT4 antibody (ab130076)Anti-FAT4 antibody (ab130076) at 1/500 dilution + recombinant FAT4 protein
Predicted band size: 543 kDa
actual MW: 48kDa
数据表及文件
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SDS download
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Datasheet download
文献 (7)
ab130076 被引用在 7 文献中.
- Li R et al. Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. Nat Commun 14:1980 (2023). PubMed: 37031213
- Malgundkar SH et al. FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and ß-catenin activity in ovarian cancer. BMC Cancer 20:374 (2020). PubMed: 32366234
- Pan M et al. MiR-106b-5p regulates the migration and invasion of colorectal cancer cells by targeting FAT4. Biosci Rep 40:N/A (2020). PubMed: 33063118
- Li Q et al. Up-regulation of FAT4 enhances the chemosensitivity of colorectal cancer cells treated by 5-FU. Transl Cancer Res 9:309-322 (2020). PubMed: 35117185
- Che X et al. FAT4-USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway. Am J Transl Res 11:2784-2800 (2019). PubMed: 31217854
- Li SY et al. Down-regulated long non-coding RNA RNAZFHX4-AS1 suppresses invasion and migration of breast cancer cells via FAT4-dependent Hippo signaling pathway. Cancer Gene Ther N/A:N/A (2018). PubMed: 30546116
- Ma L et al. Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Cancer Biol Ther 17:36-47 (2016). WB ; Human . PubMed: 26575609