JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB231190

Anti-FARS2抗体

Anti-FARS2 antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal FARS2 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Fars2.

查看别名

FARS1, HSPC320, FARS2, Phenylalanyl-tRNA synthetase, PheRS

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FARS2 antibody (AB231190)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FARS2 antibody (AB231190)

Formalin-fixed, paraffin-embedded rat kidney tissue stained for FARS2 using ab231190 at 20 mg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FARS2 antibody (AB231190)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FARS2 antibody (AB231190)

Formalin-fixed, paraffin-embedded rat stomach tissue stained for FARS2 using ab231190 at 20 mg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-FARS2 antibody (AB231190)
  • WB

Supplier Data

Western blot - Anti-FARS2 antibody (AB231190)

All lanes:

Western blot - Anti-FARS2 antibody (ab231190) at 2 µg/mL

All lanes:

HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

Predicted band size: 52 kDa

false

Western blot - Anti-FARS2 antibody (AB231190)
  • WB

Supplier Data

Western blot - Anti-FARS2 antibody (AB231190)

All lanes:

Western blot - Anti-FARS2 antibody (ab231190) at 2 µg/mL

All lanes:

Jurkat (human T cell leukemia cell line from peripheral blood) cell lysate

Predicted band size: 52 kDa,65 kDa

false

Western blot - Anti-FARS2 antibody (AB231190)
  • WB

Supplier Data

Western blot - Anti-FARS2 antibody (AB231190)

All lanes:

Western blot - Anti-FARS2 antibody (ab231190) at 2 µg/mL

All lanes:

Recombinant rat FARS2 protein

Predicted band size: 52 kDa

false

Western blot - Anti-FARS2 antibody (AB231190)
  • WB

Supplier Data

Western blot - Anti-FARS2 antibody (AB231190)

All lanes:

Western blot - Anti-FARS2 antibody (ab231190) at 2 µg/mL

All lanes:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate

Predicted band size: 52 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat, Human

应用

WB, IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Rat Fars2.

Q6AYQ3

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
存储溶液
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The enzyme known as FARS2 or mitochondrial phenylalanyl-tRNA synthetase 2 plays an important role in mitochondrial protein synthesis. It catalyzes the attachment of phenylalanine to its corresponding tRNA a process essential for translating the genetic code into proteins within mitochondria. FARS2 has a molecular mass of approximately 53 kDa and is mainly expressed in tissues with high energy demands such as brain heart and skeletal muscle. This expression pattern highlights its importance in maintaining proper mitochondrial function.
Biological function summary

FARS2 functions primarily in the mitochondrial translation machinery where it ensures the proper incorporation of phenylalanine into mitochondrial proteins. It operates as a single monomeric enzyme rather than being part of a larger complex highlighting its unique role in mitochondrial biology. Mutations affecting FARS2 can disrupt mitochondrial translation and lead to malfunction of mitochondrial respiratory chain complexes impacting cellular energy production.

Pathways

FARS2 is integral to the mitochondrial translation pathway which plays a critical role in synthesizing proteins required for the oxidative phosphorylation system. This pathway includes various mitochondrial aminoacyl-tRNA synthetases and is closely related to the oxidative phosphorylation pathway. FARS2 interacts functionally with proteins involved in the electron transport chain such as those encoded by the mitochondrial DNA to ensure efficient energy production within cells.

Mutations in FARS2 can lead to neurodegenerative conditions such as combined oxidative phosphorylation deficiency 14 and Alpers syndrome. These disorders highlight the enzyme's role in neural development and function. The disruption in mitochondrial translation caused by faulty FARS2 impacts proteins involved in the oxidative phosphorylation system such as NDUFB8 further exacerbating energy deficiency in affected tissues.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.
See full target information FARS2
style
left-column
style
left-column
style
right-column

搭配使用产品

Primary Antibodies

AB307428

Anti-MTHFD2 antibody [EPR26938-20]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-MTHFD2 antibody [EPR26938-20] (AB307428)

  • 0
  • 0
Primary Antibodies

AB181153

Anti-IREB2/IRP2 + Aconitase 1/ACO1 antibody [EPR13854]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-IREB2/IRP2 + Aconitase 1/ACO1 antibody [EPR13854] (AB181153)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB272582

Anti-TRIM35 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM35 antibody (AB272582)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com