AB5067

Anti-FANCG抗体

Name: FANCG抗体 (ab5067)| Abcam中文官网
Brand: Abcam Limited
SKU: AB5067
Price: 4606 CNY
Availability: InStock

Anti-FANCG antibody

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(6 Publications)

Rabbit Polyclonal FANCG antibody. Suitable for WB, IHC-P, ELISA and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human FANCG aa 1-50.

查看别名

XRCC9, FANCG, Fanconi anemia group G protein, Protein FACG, DNA repair protein XRCC9

1 Images

Unknown

Western blot - Anti-FANCG antibody (AB5067)

All lanes:

Western blot - Anti-FANCG antibody (ab5067) at 1/500 dilution

All lanes:

HeLa whole cell lysate at 35 µg

Secondary

All lanes:

IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution

Predicted band size: 69 kDa

Observed band size: 11 kDa,24 kDa,69 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB, ELISA

applications

免疫原

Synthetic Peptide within Human FANCG aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O15287

特异性

A BLAST analysis was used to suggest cross reactivity with FANCG protein from human and chimpanzee based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/500 - 1/2000", "IHCP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/10000 - 1/50000", "ELISA-species-notes": "" } } }

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产品详情

Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of opening.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

This affinity-purified antibody is directed against human FANCG protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification.

存储溶液

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FANCG also known as Protein FACG or Fanconi anemia group G protein is a component involved in DNA repair. It has a mass of approximately 68 kDa. This protein is mainly expressed in tissues with high proliferative rates such as bone marrow and germ cells. Mechanically FANCG plays an important role in the maintenance of genomic stability by participating in the repair processes that fix DNA interstrand crosslinks.

Biological function summary

Fanconi anemia group G protein is an essential part of the Fanconi anemia (FA) core complex which consists of several FA proteins. This complex is indispensable for cellular resistance to DNA damage as it repairs broken DNA strands and stalls replication forks. FANCG as part of this multiprotein complex ensures proper cellular responses to genotoxic stresses and helps in preventing mutations that could be passed to daughter cells.

Pathways

FANCG primarily functions within the FA/BRCA pathway an essential mechanism for DNA damage response and repair. It interacts closely with other FA proteins such as FANCA and FANCJ to facilitate the monoubiquitination of the FANCD2-FANCI complex a critical step in the DNA damage repair. Additionally the FA pathway is linked to homologous recombination repair where FANCG indirectly associates with BRCA1 and BRCA2 proteins coordinating with them to maintain genomic integrity.

Defects in FANCG are directly associated with Fanconi anemia a rare genetic disorder characterized by bone marrow failure and increased cancer susceptibility. FANCG mutations disrupt its interaction within the FA complex leading to increased cellular susceptibility to DNA damage. Moreover alterations in FA pathway components including FANCG also relate to specific cancer types such as acute myeloid leukemia. The protein engages in interactions with other FA pathway proteins like FANCD2 affecting disease progress and therapeutic outcomes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

See full target information FANCG

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Experimental & molecular medicine 55:1159-1173 PubMed37258573

2023

Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABA receptor transport in a murine model.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Liu,Pingyang Ke,Haokun Guo,Juan Gu,Yan Liu,Xin Tian,Xuefeng Wang,Fei Xiao

Antioxidants (Basel, Switzerland) 12: PubMed36978961

2023

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Wang,Ziwen Cai,Gaofeng Zhan,Xing Li,Shan Li,Xuan Wang,Shiyong Li,Ailin Luo

Frontiers in molecular neuroscience 12:275 PubMed31803018

2019

Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflectance Microscopy.

Applications

Unspecified application

Species

Unspecified reactive species

David G Gonsalvez,SangWon Yoo,Jessica L Fletcher,Rhiannon J Wood,Georgina A Craig,Simon S Murray,Junhua Xiao

Molecular pain 13:1744806917746564 PubMed29166839

2017

The synergistic effect of treatment with triptolide and MK-801 in the rat neuropathic pain model.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Wang,Yu Qiao,Ri-Sheng Yang,Chun-Kui Zhang,Huang-Hui Wu,Jia-Ji Lin,Ting Zhang,Tao Chen,Yun-Qing Li,Yu-Lin Dong,Jin-Lian Li

Brain, behavior, and immunity 60:161-173 PubMed27742579

2016

STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenpeng Song,Bingrui Xiong,Hua Zheng,Anne Manyande,Xuehai Guan,Fei Cao,Lifang Ren,Yaqun Zhou,Dawei Ye,Yuke Tian

Acta pharmacologica Sinica 37:753-62 PubMed27157092

2016

Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen-Peng Song,Bing-Rui Xiong,Xue-Hai Guan,Fei Cao,Anne Manyande,Ya-Qun Zhou,Hua Zheng,Yu-Ke Tian

View all publications

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Anti-FANCG抗体

Anti-FANCG antibody

Western blot - Anti-FANCG antibody (AB5067)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性