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AB68572

Anti-FAN1抗体

Anti-FAN1 antibody

4

(1 Review)

|

(2 Publications)

Mouse Polyclonal FAN1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FAN1.

查看别名

KIAA1018, MTMR15, FAN1, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15, hFAN1

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human FAN1.

Q9Y2M0

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替代产品

Primary Antibodies

AB222206

Anti-FAN1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-FAN1 antibody (AB222206)

  • 0
  • 0
Primary Antibodies

AB95171

Anti-FAN1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAN1 antibody (AB95171)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB223844

Anti-MLH1 antibody [EPR20522]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-MLH1 antibody [EPR20522] (AB223844)

  • 0
  • 0
Primary Antibodies

AB79398

Anti-RPA70 antibody [EPR3472]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-RPA70 antibody [EPR3472] (AB79398)

  • 5
  • 6
Primary Antibodies

AB108928

Anti-FANCD2 antibody [EPR2302]

20ul selling size|KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-FANCD2 antibody [EPR2302] (AB108928)

  • 5
  • 4
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FAN1 also known as Fanconi-associated nuclease 1 is a protein implicated in DNA repair processes. The protein has a molecular mass of approximately 101 kDa. FAN1 can be found in various tissues with enriched expression in testis thymus and liver. It operates as a nuclease engaging in processes to remove DNA crosslinks maintaining the integrity of genetic material.
Biological function summary

FAN1 plays a significant role in the repair of interstrand cross-links within DNA. FAN1 acts as part of a complex that detects and processes these cross-links aiding in cell survival by preventing genome instability. It connects with the Fanconi anemia pathway proteins which include FANCD2 and FANCI to promote the repair process. The function of FAN1 is critical in preserving cellular health under conditions that could potentially damage DNA.

Pathways

FAN1 exists prominently in the DNA damage response and the Fanconi anemia pathway. It interacts closely with proteins such as MLH1 tying into a broader network of repair mechanisms. These pathways are essential for cellular resistance to various stressors that threaten genomic stability. FAN1's precise involvement ensures cells can effectively manage DNA damage contributing to proper functioning of genetic repair networks.

FAN1 displays connections with two significant conditions: Fanconi anemia and colorectal cancer. Mutations or deficiencies in FAN1 can lead to increased susceptibility to genomic instability disorders like Fanconi anemia. The protein also associates with proteins like PMS2 and MLH1 which when mutated contribute to colorectal cancer. Understanding FAN1's role offers insight into therapeutic targets and genetic predispositions related to these conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed : 20603015, PubMed : 20603016, PubMed : 20603073, PubMed : 20671156, PubMed : 24981866, PubMed : 25430771). Not involved in DNA double-strand breaks resection (PubMed : 20603015, PubMed : 20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed : 25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed : 25430771). Also has endonuclease activity toward 5'-flaps (PubMed : 20603015, PubMed : 20603016, PubMed : 24981866).
See full target information FAN1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 80:327-344.e8 PubMed32966758

2020

PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jae Jin Kim,Seo Yun Lee,Ji-Hye Choi,Hyun Goo Woo,Blerta Xhemalce,Kyle M Miller

Archives of medical science : AMS 15:1035-1046 PubMed31360198

2019

Microarray gene profiling analysis of glioblastoma cell line U87 reveals suppression of the /Fanconi anemia pathway by the combination of Y15 and temozolomide.

Applications

Unspecified application

Species

Unspecified reactive species

Zichuan Wang,Nan Chen,Jin Yang,Qingzhong Wang,Aimin Li
View all publications
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