Anti-FAM38A/PIEZO1抗体(ab128245)
Key features and details
- Rabbit polyclonal to FAM38A/PIEZO1
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-FAM38A/PIEZO1抗体
参阅全部 FAM38A/PIEZO1 一抗 -
描述
兔多克隆抗体to FAM38A/PIEZO1 -
宿主
Rabbit -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Rabbit -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
存储溶液
Constituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128245于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ELISA |
Use at an assay dependent concentration.
|
|
WB | (2) |
1/500 - 1/2000.
|
说明 |
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ELISA
Use at an assay dependent concentration. |
WB
1/500 - 1/2000. |
靶标
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功能
Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. -
组织特异性
Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. -
序列相似性
Belongs to the PIEZO family. -
细胞定位
Endoplasmic reticulum membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 9780 Human
- Entrez Gene: 234839 Mouse
- Entrez Gene: 361430 Rat
- Omim: 611184 Human
- SwissProt: Q92508 Human
- SwissProt: E2JF22 Mouse
- SwissProt: Q0KL00 Rat
- Unigene: 377001 Human
see all -
别名
- DHS antibody
- Fam38a antibody
- Family with sequence similarity 38 member A antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (23)
ab128245 被引用在 23 文献中.
- Zhu J et al. The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation. Proc Natl Acad Sci U S A 120:e2300291120 (2023). PubMed: 37098060
- He J et al. Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism. Cell Death Discov 9:354 (2023). PubMed: 37752116
- Ke W et al. Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration. J Transl Med 21:711 (2023). PubMed: 37817199
- Fei W et al. High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma. PeerJ 11:e16306 (2023). PubMed: 37904848
- Wu Y et al. A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors. J Oncol 2022:6725570 (2022). PubMed: 35747124