AB171079

重组Anti-FAM134C抗体[EPR11765]

Anti-FAM134C antibody [EPR11765]

RabMAb
Recombinant
了解详情

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(1 Publication)

Rabbit Recombinant Monoclonal FAM134C antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

FAM134C, RETREG3, Reticulophagy regulator 3

1 Images

Supplier Data

Western blot - Anti-FAM134C antibody [EPR11765] (AB171079)

All lanes:

Western blot - Anti-FAM134C antibody [EPR11765] (ab171079) at 1/1000 dilution

Lane 1:

MCF7 cell lysate at 10 µg

Lane 2:

HepG2 cell lysate at 10 µg

Lane 3:

Human fetal liver tissue lysate at 10 µg

Lane 4:

T47D cell lysate at 10 µg

Lane 5:

Human fetal brain tissue lysate at 10 µg

Predicted band size: 51 kDa

false

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR11765

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: BSA, Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FAM134C also known as family with sequence similarity 134 member C is a protein involved in autophagy processes. It has a molecular mass of approximately 54 kDa. This protein localizes mainly within the endoplasmic reticulum (ER) membrane and it is expressed in several tissues including the brain and liver. FAM134C plays an essential role in regulating the ER shape and maintaining cellular homeostasis.

Biological function summary

The protein participates in the process of selective autophagy particularly ER-phagy which is the degradation of ER fragments. This function indicates that it is part of a broader complex that regulates the destruction of damaged or excessive organelles which is important for neuron and liver cell function. FAM134C interacts with LC3 proteins during these processes acting as a receptor that identifies ER regions targeted for degradation.

Pathways

Researchers recognize FAM134C's involvement in the cellular pathway of autophagy and apoptosis. The protein operates within these pathways by interacting with other autophagy-related proteins such as ATG8 family members which aid in forming autophagosomes. These pathways influence the balance between cell survival and cell death showcasing the protein's role in maintaining cellular health and function.

Studies indicate a connection of FAM134C to neurodegenerative diseases and cancer. Dysregulation of its function can lead to the accumulation of damaged organelles contributing to neurodegenerative conditions like Alzheimer's disease. Moreover aberrant expression levels of FAM134C have been noted in certain cancer types suggesting its involvement in cancer progression. Disorders involving this protein often also implicate the LC3 protein reinforcing its participation in pathways related to pathological conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed : 34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed : 34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed : 33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed : 26040720).

See full target information RETREG3

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 132: PubMed36066968

2022

BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Guizhen Zhao,Yang Zhao,Haocheng Lu,Ziyi Chang,Hongyu Liu,Huilun Wang,Wenying Liang,Yuhao Liu,Tianqing Zhu,Oren Rom,Yanhong Guo,Lin Chang,Bo Yang,Minerva T Garcia-Barrio,Jiandie D Lin,Y Eugene Chen,Jifeng Zhang

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

重组Anti-FAM134C抗体[EPR11765]

Anti-FAM134C antibody [EPR11765]

Western blot - Anti-FAM134C antibody [EPR11765] (AB171079)

关键信息

宿主种属

克隆

克隆号

亚型

不含载体蛋白

反应种属

应用

免疫原