AB202125

Anti-FAM134C抗体- C-terminal

Name: FAM134C抗体- C-terminal (ab202125)| Abcam中文官网
Brand: Abcam Limited
SKU: AB202125
Price: 4606 CNY
Availability: InStock
Rating: 3 (2 reviews)

Anti-FAM134C antibody - C-terminal

(2 Reviews)

(2 Publications)

Rabbit Polyclonal FAM134C antibody. C-terminal. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human RETREG3 aa 400 to C-terminus.

查看别名

FAM134C, RETREG3, Reticulophagy regulator 3

2 Images

Supplier Data

Immunoprecipitation - Anti-FAM134C antibody - C-terminal (AB202125)

Lane 1 : Detection of FAM134C in immunoprecipitates of 293T whole cell lysate (prepared using NETN lysis buffer; 0.5 or 1.0 mg per IP reaction, 20% of IP loaded) using ab202125 at 6 μg per reaction, and at 1 μg/ml for subsequent Western blot detection.
Lane 2 : controle IgG
Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-FAM134C antibody - C-terminal (ab202125)

Predicted band size: 51 kDa

true

Exposure time: 10s

Supplier Data

Western blot - Anti-FAM134C antibody - C-terminal (AB202125)

All lanes:

Western blot - Anti-FAM134C antibody - C-terminal (ab202125) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Predicted band size: 51 kDa

true

Exposure time: 30s

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IP, WB

applications

免疫原

Synthetic Peptide within Human RETREG3 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q86VR2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

FAM134C also known as family with sequence similarity 134 member C is a protein involved in autophagy processes. It has a molecular mass of approximately 54 kDa. This protein localizes mainly within the endoplasmic reticulum (ER) membrane and it is expressed in several tissues including the brain and liver. FAM134C plays an essential role in regulating the ER shape and maintaining cellular homeostasis.

Biological function summary

The protein participates in the process of selective autophagy particularly ER-phagy which is the degradation of ER fragments. This function indicates that it is part of a broader complex that regulates the destruction of damaged or excessive organelles which is important for neuron and liver cell function. FAM134C interacts with LC3 proteins during these processes acting as a receptor that identifies ER regions targeted for degradation.

Pathways

Researchers recognize FAM134C's involvement in the cellular pathway of autophagy and apoptosis. The protein operates within these pathways by interacting with other autophagy-related proteins such as ATG8 family members which aid in forming autophagosomes. These pathways influence the balance between cell survival and cell death showcasing the protein's role in maintaining cellular health and function.

Studies indicate a connection of FAM134C to neurodegenerative diseases and cancer. Dysregulation of its function can lead to the accumulation of damaged organelles contributing to neurodegenerative conditions like Alzheimer's disease. Moreover aberrant expression levels of FAM134C have been noted in certain cancer types suggesting its involvement in cancer progression. Disorders involving this protein often also implicate the LC3 protein reinforcing its participation in pathways related to pathological conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed : 34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed : 34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed : 33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed : 26040720).

See full target information RETREG3

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:2698 PubMed37164963

2023

Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Lan,Sophie Wilhelmina van Leur,Julia Ayano Fernando,Ho Him Wong,Martin Kampmann,Lewis Siu,Jingshu Zhang,Mingyuan Li,John M Nicholls,Sumana Sanyal

European journal of medical research 27:205 PubMed36253873

2022

Construction of mRNA prognosis signature associated with differentially expressed genes in early stage of stomach adenocarcinomas based on TCGA and GEO datasets.

Applications

Unspecified application

Species

Unspecified reactive species

Fuquan Jiang,Haiguan Lin,Hongfeng Yan,Xiaomin Sun,Jianwu Yang,Manku Dong

View all publications

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Anti-FAM134C抗体- C-terminal

Anti-FAM134C antibody - C-terminal

Immunoprecipitation - Anti-FAM134C antibody - C-terminal (AB202125)

Western blot - Anti-FAM134C antibody - C-terminal (AB202125)