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AB104557

Anti-Factor XII 抗体

Anti-Factor XII antibody

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(1 Publication)

Goat Polyclonal Factor XII antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

查看别名

Coagulation factor XII, Hageman factor, HAF, F12

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XII antibody (AB104557)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XII antibody (AB104557)

Human Kidney (formalin-fixed, paraffin-embedded) stained with ab104557 at 5 μg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XII antibody (AB104557)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XII antibody (AB104557)

Human Testis (formalin-fixed, paraffin-embedded) stained with ab104557 at 5 μg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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性能和储存信息

形式
Liquid
纯化工艺
Precipitation Ammonium Sulphate
存储溶液
pH: 7.4 Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Factor XII also known as FXII or Hageman factor is a serine protease and a coagulation factor that plays an important role in initiating the intrinsic pathway of blood coagulation. It has a molecular mass of approximately 80 kDa. The liver primarily synthesizes this protein and it circulates in the blood plasma as an inactive precursor. When activated to Factor XIIa it cleaves and activates other coagulation factors such as Factor XI to propagate the coagulation cascade that helps in blood clot formation.
Biological function summary

This protein helps control blood coagulation processes as part of a larger network of interacting proteins that includes contact activation factors. Factor XII activates not only the coagulation cascade but also pathways involved in fibrinolysis inflammation and bradykinin formation. It triggers the kallikrein-kinin system and leads to the generation of bradykinin a peptide known to induce vascular permeability and inflammation.

Pathways

The involvement of Factor XII spans the intrinsic coagulation pathway and the kallikrein-kinin system. It interacts with several other coagulation factors such as Factor XI and prekallikrein to advance the clotting process. The protein initiates the intrinsic blood coagulation pathway by converting Factor XI to Factor XIa in the presence of negatively charged surfaces. It links to the fibrinolytic pathway and can indirectly activate plasminogen through interactions that generate plasmin.

Factor XII deficiency leads to increased risk of thrombosis even though such deficiency generally shows no major bleeding symptoms. The target links to hereditary angioedema where dysregulation in the kallikrein-kinin system involves premature bradykinin activity. Factor XII associates with C1-inhibitor a protein playing a regulatory role in preventing excessive bradykinin production which can manifest in clinical symptoms seen in hereditary angioedema patients.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (PubMed : 2019570, PubMed : 21304106, PubMed : 8427954).
See full target information F12
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular and cellular cardiology 179:47-59 PubMed37003353

2023

InsPR-RyR channel crosstalk augments sarcoplasmic reticulum Ca release and arrhythmogenic activity in post-MI pig cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jin,Anna Meletiou,Joshua Chung,Agne Tilunaite,Kateryna Demydenko,Eef Dries,Rosa Doñate Puertas,Matthew Amoni,Ashutosh Tomar,Guillaume Gilbert,Piet Claus,Christian Soeller,Vijay Rajagopal,Karin Sipido,H Llewelyn Roderick
View all publications
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替代产品

Primary Antibodies

AB196670

Anti-Factor XII antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XII antibody - C-terminal (AB196670)

  • 0
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Primary Antibodies

AB242123

Anti-Factor XII antibody [EPR22292-127]

RabMAb|Recombinant|Trial Size

Western blot - Anti-Factor XII antibody [EPR22292-127] (AB242123)

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Primary Antibodies

AB242152

Anti-Factor XII antibody [EPR22292-127] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Factor XII antibody [EPR22292-127] - BSA and Azide free (AB242152)

  • 0
  • 0

搭配使用产品

Assay Kits

AB241041

Factor XII / XIIa Assay Kit

Functional Studies - Factor XII / XIIa Assay Kit (AB241041)

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Primary Antibodies

AB92621

Anti-Thrombin antibody

Western blot - Anti-Thrombin antibody (AB92621)

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Primary Antibodies

AB255824

Anti-Factor IX/PTC antibody [EPR22846-238]

RabMAb|Recombinant

Immunoprecipitation - Anti-Factor IX/PTC antibody [EPR22846-238] (AB255824)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB232726

Anti-Factor XIa antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIa antibody (AB232726)

  • 0
  • 0

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