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AB232726

Anti-Factor XIa抗体

Anti-Factor XIa antibody

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(1 Publication)

Rabbit Polyclonal FXI antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication.

查看别名

Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, F11

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIa antibody (AB232726)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIa antibody (AB232726)

Formalin-fixed, paraffin-embedded rat liver tissue stained for Factor XIa using ab232726 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Factor XIa antibody (AB232726)
  • WB

Supplier Data

Western blot - Anti-Factor XIa antibody (AB232726)

All lanes:

Western blot - Anti-Factor XIa antibody (ab232726) at 2 µg/mL

All lanes:

HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

Predicted band size: 70 kDa

false

Western blot - Anti-Factor XIa antibody (AB232726)
  • WB

Supplier Data

Western blot - Anti-Factor XIa antibody (AB232726)

All lanes:

Western blot - Anti-Factor XIa antibody (ab232726) at 2 µg/mL

All lanes:

Recombinant rat Factor XIa protein

Predicted band size: 70 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Rat, Human

应用

WB, IHC-P

applications

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
纯化说明
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
存储溶液
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Factor XIa also known as Coagulation Factor XIa or FXIa plays an important role in the blood coagulation cascade. This serine protease has a molecular weight of approximately 160 kDa and derives from the zymogen Factor XI. Factor XIa is synthesized in the liver and circulates in the blood plasma. In its active form it cleaves the Arg369-Ile370 bond in Factor IX leading to the further activation of the coagulation pathway.
Biological function summary

Factor XIa is essential for hemostasis. It forms a part of the intrinsic pathway complex that contributes to the amplification of thrombin generation. This activity strengthens the formation of a stable fibrin clot which is critical to prevent excessive bleeding. Factor XIa is also involved in cellular response mechanisms beyond coagulation such as inflammatory processes.

Pathways

Factor XIa is a significant component of the intrinsic coagulation pathway and the contact activation system. It works closely with proteins like Factor IX and kallikrein facilitating the transformation of inactive proteins to their active states in a stepwise manner. These interactions support hemostatic balance and help maintain proper clot formation while preventing thrombosis.

Factor XIa has connections to thrombotic conditions such as deep vein thrombosis and ischemic stroke. Excessive activation of FXIa can contribute to pathological clot formation. Inhibitors like anti-XIa reduce activity and are explored for therapeutic interventions in these conditions. Additionally congenital Factor XI deficiency often called Hemophilia C presents a bleeding disorder that highlights FXIa's significance in coagulation.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
See full target information F11
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Aging cell 23:e14320 PubMed39158018

2024

Single-cell RNA sequencing reveals the CRTAC1 population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1 macrophage.

Applications

Unspecified application

Species

Unspecified reactive species

Yulong Tang,Dachun Zhuo,Yuexin Yu,Weilin Pu,Yanyun Ma,Yuting Zhang,Yan Huang,Qing Zhang,Kunhai Tang,Chen Meng,Di Yang,Lu Bai,Dongyi He,Li Jin,Hejian Zou,Huji Xu,Qi Zhu,Jiucun Wang,Yuanyuan Chen,Jing Liu
View all publications
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