Anti-Factor XIa抗体(ab100878)
Key features and details
- Rabbit polyclonal to Factor XIa
- Suitable for: ELISA
- Reacts with: Cow
- Isotype: IgG
概述
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产品名称
Anti-Factor XIa抗体
参阅全部 Factor XIa 一抗 -
描述
兔多克隆抗体to Factor XIa -
宿主
Rabbit -
经测试应用
适用于: ELISAmore details -
种属反应性
与反应: Cow -
免疫原
Full length native protein Bovine FXIa purified from bovine plasma
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.50
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab100878于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
The antibody sensitivity is at 10pg/ml. |
| 说明 |
|---|
|
ELISA
Use at an assay dependent concentration. The antibody sensitivity is at 10pg/ml. |
靶标
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功能
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. -
组织特异性
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. -
疾病相关
Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. -
序列相似性
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
翻译后修饰
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 407998 Cow
- SwissProt: Q5NTB3 Cow
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别名
- coagulation factor XI antibody
- Coagulation factor XIa light chain antibody
- F11 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab100878 尚未被引用在任何文献中。