Anti-Factor Xa Heavy Chain抗体(ab180701)
Key features and details
- Rabbit polyclonal to Factor Xa Heavy Chain
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Factor Xa Heavy Chain抗体
参阅全部 Factor Xa Heavy Chain 一抗 -
描述
兔多克隆抗体to Factor Xa Heavy Chain -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rat
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免疫原
Recombinant fragment corresponding to Human Factor Xa Heavy Chain aa 235-488.
Sequence:IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY VDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITS SPLK
Database link: P00742 -
阳性对照
- HepG2 cell extract.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab180701于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 55 kDa.
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| 说明 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 55 kDa. |
靶标
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功能
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. -
组织特异性
Plasma; synthesized in the liver. -
疾病相关
Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. -
序列相似性
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
翻译后修饰
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 2159 Human
- Entrez Gene: 29243 Rat
- Omim: 613872 Human
- SwissProt: P00742 Human
- SwissProt: Q63207 Rat
- Unigene: 361463 Human
- Unigene: 21393 Rat
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别名
- Activated factor Xa heavy chain antibody
- Coagulation factor X antibody
- F10 antibody
see all
图片
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Western blot - Anti-Factor Xa Heavy Chain antibody (ab180701)Anti-Factor Xa Heavy Chain antibody (ab180701) at 1/500 dilution + HepG2 cell extract
Predicted band size: 55 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab180701 被引用在 1 文献中.
- Schuliga M et al. Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity. Am J Physiol Lung Cell Mol Physiol 312:L772-L782 (2017). PubMed: 28283478