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AB17932

Anti-Factor B抗体[9B8]

Anti-Factor B antibody [9B8]

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(1 Publication)

Anti-Factor B antibody [9B8] (ab17932) is a mouse monoclonal antibody detecting Factor B in Western Blot, ELISA. Suitable for Human.

- Trusted since 2005

查看别名

BF, BFD, CFB, Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, PBF2, Properdin factor B, GBG

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

9B8

亚型

IgG1

轻链类型

kappa

不含载体蛋白

No

反应种属

Human

应用

WB, ELISA

applications

免疫原

Native Full Length Protein corresponding to Human CFB.

P00751

特异性

ab17932 is specific for the Bb fragment of human factor B. In Western blotting, after SDS-PAGE, this antibody reacts with the Bb fragment of factor B in non-reduced form only. Antibody binding abolishes the formation of C3bBb complexes.

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反应性数据

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我们建议您务必查阅产品说明书，以确认其是否符合您的实验需求；若有疑问，也可联系我们的技术团队获取协助。

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产品详情

What is this antibody validated in?
Anti-Factor B antibody [9B8] (ab17932) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), ELISA in Human samples.
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: 2.9% Sodium chloride, 0.0268% PBS
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Factor B also known as B-factor is a protein that plays an important role in the immune system specifically in the complement pathway. It is sometimes referred to as factor B complement and its gene identifier is often referenced as KY21 NNL or factor B 1001. Factor B has a molecular mass of approximately 93 kDa. It is mainly expressed in the liver but can also be found in blood plasma in its inactive form as part of the innate immune response.
Biological function summary

Factor B is involved in the alternative complement pathway which serves as a part of the body's defense mechanism. It participates in the formation of the C3 convertase together with factor D and properdin initiating a cascade that can lead to the opsonization and elimination of pathogens. Factor B undergoes cleavage by factor D which generates the Ba and Bb fragments with Bb functioning as a serine protease within the C3 convertase complex.

Pathways

Factor B contributes to the complement system interacting notably in the alternative and lectin pathways. In these pathways Factor B associates with proteins like complement component C3. The alternative pathway is activated on microbial surfaces independent of antibodies. The involvement of Factor B in these pathways illustrates its role in pathogen recognition and further highlights its cooperation with complement proteins such as C3 and properdin.

Factor B has been associated with atypical hemolytic uremic syndrome (aHUS) a rare and serious disease affecting kidney function. Factor B involvement in aHUS links it to abnormal complement activation leading to a pathological condition. Additionally Factor B connects to age-related macular degeneration (AMD) a disorder where complement pathway genetic variations including those involving Factor B have shown associations. Understanding interactions with other complement components such as factor H helps to elucidate its role in these diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments : Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
See full target information CFB
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:639980 PubMed33898314

2021

LncRNA LIPE-AS1 Predicts Poor Survival of Cervical Cancer and Promotes Its Proliferation and Migration via Modulating miR-195-5p/MAPK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zhang,Pinping Jiang,Shoyu Wang,Wenjun Cheng,Shilong Fu
View all publications
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Abcam Product Promise

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详情请参阅我们的条款与条件。
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