Anti-EYA4抗体(ab110148)
Key features and details
- Goat polyclonal to EYA4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-EYA4抗体
参阅全部 EYA4 一抗 -
描述
山羊多克隆抗体to EYA4 -
宿主
Goat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse
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免疫原
Synthetic peptide: DSQDLNEQSVKKTC, corresponding to N terminal amino acids 2-16 of Human EYA4 (UniProt ID: O95677).
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阳性对照
- Human liver and testis tissues
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110148于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 3.75 µg/ml.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 3.75 µg/ml. |
靶标
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功能
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye. -
组织特异性
Highly expressed in heart and skeletal muscle. -
疾病相关
Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10) [MIM:601316]. DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J) [MIM:605362]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. -
序列相似性
Belongs to the HAD-like hydrolase superfamily. EYA family. -
细胞定位
Cytoplasm. Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 2070 Human
- Entrez Gene: 14051 Mouse
- Omim: 603550 Human
- SwissProt: O95677 Human
- SwissProt: Q9Z191 Mouse
- Unigene: 596680 Human
- Unigene: 332128 Mouse
- Unigene: 446298 Mouse
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别名
- CMD1J antibody
- Deafness, autosomal dominant 10 antibody
- DFNA 10 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (ab110148)ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human liver by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (ab110148)ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human testis by Immunohistochemistry.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab110148 尚未被引用在任何文献中。