AB110148

Anti-EYA4抗体

Name: EYA4抗体 (ab110148)| Abcam中文官网
Brand: Abcam Limited
SKU: AB110148
Price: 4606 CNY
Availability: InStock

Anti-EYA4 antibody

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(1 Publication)

Goat Polyclonal EYA4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EYA4 aa 1-50.

查看别名

Eyes absent homolog 4, EYA4

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (AB110148)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (AB110148)

ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human liver by Immunohistochemistry.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (AB110148)

ab110148, at 3.75 µg/ml, staining EYA4 in formalin fixed, paraffin embedded Human testis by Immunohistochemistry.

关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human EYA4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O95677

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

EYA4 also known as Eyes Absent 4 is a protein involved in several important cellular processes. It has an approximate molecular mass of 64 kDa. This protein acts as a phosphatase removing phosphate groups from specific proteins. EYA4 is expressed in various tissues including the heart brain and kidneys. Its presence in these diverse tissues indicates its importance in multiple cellular functions.

Biological function summary

EYA4 contributes to the DNA damage repair process and is important for normal cellular development and function. The protein exists as part of a transcriptional complex often interacting with other proteins to regulate gene expression. This interaction suggests a role in cellular differentiation and proliferation supporting healthy developmental processes and maintaining cell health over time.

Pathways

EYA4 plays an integral role in the Notch signaling and DNA repair pathways. In the Notch signaling pathway it associates with the transcription co-activator protein YAP to influence cell fate decisions. This involvement highlights its importance in cellular architecture maintenance. Its function in the DNA repair pathway further links it with the ATM protein coordinating effective responses to genomic stress and preserving genomic integrity.

Alterations in EYA4 expression or function can contribute to sensorineural hearing loss and certain types of cancer including breast cancer. Defective EYA4 interactions with the protein SIX1 have been linked to hearing impairments. In cancer biology aberrant EYA4 function may disrupt its DNA repair capability facilitating genomic instability and tumor progression indicating a critical role in maintaining cellular homeostasis and preventing disease.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).

See full target information EYA4

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of comparative neurology 528:2161-2173 PubMed32037591

2020

Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

Ivan Mestres,Maximilian Einsiedel,June Möller,Beatriz Cardoso de Toledo

View all publications

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Anti-EYA4抗体

Anti-EYA4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (AB110148)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EYA4 antibody (AB110148)