AB118798

Anti-EXOC1抗体

Name: EXOC1抗体 (ab118798)| Abcam中文官网
Brand: Abcam Limited
SKU: AB118798
Price: 4606 CNY
Availability: InStock
Rating: 4 (1 reviews)

Anti-EXOC1 antibody

(1 Review)

(4 Publications)

Rabbit Polyclonal EXOC1 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human EXOC1 aa 100-150.

查看别名

SEC3, SEC3L1, BM-012, EXOC1, Exocyst complex component 1, Exocyst complex component Sec3

2 Images

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Immunoprecipitation - Anti-EXOC1 antibody (AB118798)

Detection of EXOC1 in Immunoprecipitates of HeLa whole cell lysates (1 mg for IP, 20% of IP loaded) using ab118798 at 6 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot detection.
Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-EXOC1 antibody (ab118798)

Predicted band size: 102 kDa

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Unknown

Western blot - Anti-EXOC1 antibody (AB118798)

All lanes:

Western blot - Anti-EXOC1 antibody (ab118798) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

293T whole cell lysate at 50 µg

Lane 4:

Jurkat whole cell lysate at 50 µg

Lane 5:

NIH3T3 whole cell lysate at 50 µg

Predicted band size: 102 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

IP, WB

applications

免疫原

Synthetic Peptide within Human EXOC1 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.

Q9NV70

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

EXOC1 also known as Exocyst Complex Component 1 is part of the exocyst complex which plays an essential role in vesicle trafficking. The protein works within a large complex that aids in the tethering of secretory vesicles to specific areas of the plasma membrane before fusion. EXOC1 consists of 97 kDa and is the component of the exocyst complex expressed in numerous tissues with high expression in the brain and liver.

Biological function summary

The exocyst complex supports protein and lipid distribution at the cell surface which influences cell signaling growth and differentiation. EXOC1 as a component of this complex contributes to orchestrated membrane dynamics. The exocyst complex includes other proteins such as EXOC3 EXOC4 and SEC10 and together it achieves targeted delivery of vesicles which is necessary for cellular expansion.

Pathways

The exocyst complex including EXOC1 is involved in the exocytosis pathway where it supports the transport of vesicles from the Golgi to the plasma membrane. This protein plays a role alongside small GTPases notably Rho and Rab which regulate vesicular trafficking. EXOC1 associates with the mTOR signaling pathway where it influences cellular growth and metabolism through its role in vesicle targeting.

EXOC1 is linked with conditions such as cancer and diabetes. Its role in vesicle trafficking implicates it in tumor progression where alterations in exocyst complex components disrupt cellular secretion and promote cancerous behaviors. The involvement in the mTOR pathway associates EXOC1 with metabolic disorders such as type 2 diabetes where dysfunctional signaling affects insulin response. Changes in expression levels or mutations in EXOC1 can influence disease states affecting proteins like Rho GTPases within these complexes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.. (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation.

See full target information EXOC1

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 222: PubMed36920342

2023

The exocyst complex is an essential component of the mammalian constitutive secretory pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Conceição Pereira,Danièle Stalder,Georgina S F Anderson,Amber S Shun-Shion,Jack Houghton,Robin Antrobus,Michael A Chapman,Daniel J Fazakerley,David C Gershlick

Journal of neurochemistry 160:203-217 PubMed34862972

2021

Sec3 exocyst component knockdown inhibits axonal formation and cortical neuronal migration during brain cortex development.

Applications

Unspecified application

Species

Unspecified reactive species

Florentyna Bustos Plonka,Lucas J Sosa,Santiago Quiroga

The Journal of cell biology 217:3863-3872 PubMed30275106

2018

remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers.

Applications

Unspecified application

Species

Unspecified reactive species

Kohei Arasaki,Hana Kimura,Mitsuo Tagaya,Craig R Roy

International journal of oncology 53:266-274 PubMed29749468

2018

Inhibition of CD9 expression reduces the metastatic capacity of human hepatocellular carcinoma cell line MHCC97-H.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Lin,Shifang Peng,Yixuan Yang

View all publications

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Anti-EXOC1抗体

Anti-EXOC1 antibody

Immunoprecipitation - Anti-EXOC1 antibody (AB118798)

Western blot - Anti-EXOC1 antibody (AB118798)