AB223705

Anti-ETV6 / Tel抗体

Name: ETV6 / Tel抗体 (ab223705)| Abcam中文官网
Brand: Abcam Limited
SKU: AB223705
Price: 5930 CNY
Availability: InStock

Anti-ETV6 / Tel antibody

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(1 Publication)

Rabbit Polyclonal ETV6 / Tel antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ETV6 aa 50-250.

查看别名

TEL, TEL1, ETV6, Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel

6 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Immunohistochemical analysis of human skin tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Immunohistochemical analysis of human kidney tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution. No staining is observed.

Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB223705)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB223705)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for ETV6 / Tel (green) using ab223705 at 4 μg/ml in ICC/IF.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Immunohistochemical analysis of human breast tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Immunohistochemical analysis of human liver tissue labeling ETV6 / Tel with ab223705 at 1/200 dilution. No staining is observed.

Supplier Data

Western blot - Anti-ETV6 / Tel antibody (AB223705)

All lanes:

Western blot - Anti-ETV6 / Tel antibody (ab223705) at 0.4 µg/mL

Lane 1:

U-2-OS cell lysate

Lane 2:

CACO-2 cell lysate

Predicted band size: 53 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ETV6 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.

P41212

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "Fixation/Permeabilization: PFA/Triton X-100." }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ETV6 also known as Tel is a transcription factor encoded by the ETV6 gene. It weighs approximately 57 kDa. The protein is expressed in various tissues including hematopoietic cells which are cells that form blood cells. ETV6 contains a pointed (PNT) domain and an ETS DNA-binding domain which allow it to regulate gene expression by binding to specific DNA sequences. It functions in the nucleus where it influences cell cycle progression and differentiation.

Biological function summary

ETV6 impacts processes key to hematopoiesis and is often part of transcriptional regulatory complexes. It guides critical decisions in hematopoietic stem cells promoting lineage commitment and modulating cell cycle regulation. This protein acts as a repressor or activator depending on the context influencing target gene expression and sustaining the balance necessary for blood cell differentiation and maintenance. Its ability to interact with co-factors like HDACs (histone deacetylases) broadens its regulatory potential.

Pathways

ETV6 integrates into signaling pathways that manage cellular development and proliferation. ETV6 participates in the Ras-MAPK pathway which influences cell growth by regulating transcription of genes essential for these processes. It also interacts closely with proteins like ABL1 in this pathway modulating both kinase activity and gene control highlighting the critical connections it maintains in cell signaling networks.

ETV6 exhibits pivotal roles in oncogenic processes such as those observed in leukemia. Its involvement in translocation events like the ETV6-RUNX1 fusion contributes to the pathogenesis of acute lymphoblastic leukemia (ALL) by altering normal gene regulation. Additionally mutations within ETV6 link it to myelodysplastic syndromes with associated proteins in these disorders including FLT3. This connection highlights the pathogenic impact ETV6 permutations can have within hematological malignancies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.

See full target information ETV6

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 133: PubMed36928117

2023

Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction.

Applications

Unspecified application

Species

Unspecified reactive species

Mrinal K Sarkar,Ranjitha Uppala,Chang Zeng,Allison C Billi,Lam C Tsoi,Austin Kidder,Xianying Xing,Bethany E Perez White,Shuai Shao,Olesya Plazyo,Sirisha Sirobhushanam,Enze Xing,Yanyun Jiang,Katherine A Gallagher,John J Voorhees,J Michelle Kahlenberg,Johann E Gudjonsson

View all publications

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Anti-ETV6 / Tel抗体

Anti-ETV6 / Tel antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB223705)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

Western blot - Anti-ETV6 / Tel antibody (AB223705)