Anti-ERp72 抗体
Anti-ERp72 antibody
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(15 Publications)
Rabbit Polyclonal ERp72 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 15 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDIA4 aa 350 to C-terminus.
查看别名
ERP70, ERP72, PDIA4, Protein disulfide-isomerase A4, Endoplasmic reticulum resident protein 70, Endoplasmic reticulum resident protein 72, ER protein 70, ERp70, ER protein 72, ERp-72, ERp72
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-ERp72 antibody (AB155800)
Confocal immunofluorescence analysis of methanol-fixed HeLa cells labeling ERp72 with ab155800 at 1/500 dilution (green). Bottom image shows merger with nuclear staining (blue).
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ERp72 antibody (AB155800)
Immunohistochemical analysis of paraffin-embedded Human Breast carcinoma tissue labeling ERp72with ab155800 at 1/500 dilution.
- WB
Unknown
Western blot - Anti-ERp72 antibody (AB155800)
7.5% SDS PAGE
All lanes:
Western blot - Anti-ERp72 antibody (ab155800) at 1/10000 dilution
Lane 1:
NIH-3T3 whole cell lysate at 30 µg
Lane 2:
JC whole cell lysate at 30 µg
Lane 3:
BCL-1 whole cell lysate at 30 µg
Predicted band size: 73 kDa
false
- WB
Unknown
Western blot - Anti-ERp72 antibody (AB155800)
7.5% SDS PAGE
All lanes:
Western blot - Anti-ERp72 antibody (ab155800) at 1/1000 dilution
Lane 1:
293T whole cell lysate at 30 µg
Lane 2:
A431 whole cell lysate at 30 µg
Predicted band size: 73 kDa
false
反应性数据
性能和储存信息
形式
纯化工艺
存储溶液
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein disulfide isomerase family member ERp72 plays a significant part in maintaining ER function. It participates in the unfolded protein response (UPR) which ensures proper protein folding and manages ER stress. ERp72 operates as part of a larger multiprotein complex that aids in the quality control of newly synthesized proteins. The protein interacts with calnexin and BiP to perform these functions. This makes ERp72 essential for cellular homeostasis and adaptation to changing physiological conditions.
Pathways
ERp72 is closely involved in the protein folding and ER stress response pathways. The unfolded protein response pathway recognizes misfolded proteins in the ER and initiates mechanisms to restore normal function. It connects with other proteins such as ATF6 and IRE1 to modulate gene expression and improve protein folding capacity. Additionally ERp72 participates in the pathway related to oxidative protein folding working alongside proteins like ERO1. This confirms its key contribution to cellular function by maintaining the balance between protein folding and degradation.
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文献 (15)
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Nature communications 16:7699 PubMed40825974
2025
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Nature communications 16:2535 PubMed40087276
2025
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Cell reports. Medicine 6:101917 PubMed39809267
2025
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The breast journal 2023:3970444 PubMed37720188
2023
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iScience 26:106328 PubMed36968068
2023
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Cell chemical biology 30:22-42.e5 PubMed36630963
2023
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The EMBO journal 42:e111869 PubMed36245281
2022
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International journal of molecular sciences 22: PubMed34884824
2021
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eLife 10: PubMed34190687
2021
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Immunity, inflammation and disease 9:108-119 PubMed33159506
2020
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