Anti-Endothelium抗体[PAL-E] (ab8086)
Key features and details
- Mouse monoclonal [PAL-E] to Endothelium
- Suitable for: IHC-Fr
- Reacts with: Rabbit, Goat, Dog, Human, Pig
- Isotype: IgG2a
概述
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产品名称
Anti-Endothelium抗体[PAL-E]
参阅全部 Endothelium 一抗 -
描述
小鼠单克隆抗体[PAL-E] to Endothelium -
宿主
Mouse -
特异性
Reactivity with: Lymphatic endothelium :not detectable. Sinus histiocytes :not detectable. Megakaryocytes :not detectable. -
经测试应用
适用于: IHC-Frmore details
不适用于: WB -
种属反应性
与反应: Rabbit, Goat, Dog, Human, Pig
不与反应: Mouse, Rat, Chicken -
免疫原
Tissue, cells or virus corresponding to Human Endothelium.
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阳性对照
- IHC-Fr: human spleen tissue
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常规说明
The antibody only stains human and various animal (goat, rabbit, pig, dog) blood vessels with the exception of arteries.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.3
Preservative: 0.07% Sodium azide -
Concentration information loading...
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纯度
Tissue culture supernatant -
Primary antibody说明
The antibody only stains human and various animal (goat, rabbit, pig, dog) blood vessels with the exception of arteries. -
克隆
单克隆 -
克隆编号
PAL-E -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
应用 | Ab评论 | 说明 |
---|---|---|
IHC-Fr | (1) |
1/100.
Fix with acetone. |
说明 |
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IHC-Fr
1/100. Fix with acetone. |
靶标
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相关性
The endothelium is located at the interface between the blood and the vessel wall. The cells are in close contact and form a slick layer that prevents blood cell interaction with the vessel wall as blood moves through the vessel lumen. The endothelium consists of simple squamous epithelium that lines the lumen of all blood vessels. It plays a critical role in the mechanics of blood flow, the regulation of coagulation, leukocyte adhesion, and vascular smooth muscle cell growth, and also serves as a barrier to the transvascular diffusion of liquids and solutes. For years the endothelium was thought of as an inert single layer of cells that passively allow the passage of water and other small molecules across the vessel wall. However, this dynamic tissue performs many other active functions, such as the secretion and modification of vasoactive substances and the contraction and relaxation of vascular smooth muscle.
图片
数据表及文件
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Datasheet download
文献 (12)
ab8086 被引用在 12 文献中.
- Wilkinson AL et al. The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration. iScience 26:107966 (2023). PubMed: 37810232
- Elkadri A et al. Mutations in Plasmalemma Vesicle Associated Protein Result in Sieving Protein-Losing Enteropathy Characterized by Hypoproteinemia, Hypoalbuminemia, and Hypertriglyceridemia. Cell Mol Gastroenterol Hepatol 1:381-394.e7 (2015). PubMed: 26207260
- Keuschnigg J et al. Plasticity of blood- and lymphatic endothelial cells and marker identification. PLoS One 8:e74293 (2013). PubMed: 24058540
- Park SS et al. Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34+ cells in NOD-SCID mice with acute ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 53:986-94 (2012). PubMed: 22247454
- Moussai D et al. The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C. J Invest Dermatol 131:229-36 (2011). PubMed: 20827282