AB130402

Anti-ELOF1抗体

Name: ELOF1抗体 (ab130402)| Abcam中文官网
Brand: Abcam Limited
SKU: AB130402
Price: 5930 CNY
Availability: InStock

Anti-ELOF1 antibody

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(1 Publication)

Rabbit Polyclonal ELOF1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ELOF1 aa 1 to C-terminus.

查看别名

Transcription elongation factor 1 homolog, ELOF1

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-ELOF1 antibody (AB130402)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ELOF1 antibody (AB130402)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in cytoplasm. Recommended concentration of ab130402 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOF1 antibody (AB130402)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOF1 antibody (AB130402)

Immunohistochemical analysis of Formalin-fixed, paraffin embedded Human lateral ventricle tissue labelled with ELOF1 antibody at 1/10 dilution.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ELOF1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P60002

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/20", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ELOF1 known as Elongation Factor Protein 1 plays a role in the transcription process. It assists RNA polymerase II with transcription elongation and maintaining transcript integrity. ELOF1 has a molecular weight of approximately 15 kDa. It is expressed in various tissues with higher levels found in active proliferating cells due to its role in gene expression regulation.

Biological function summary

ELOF1 supports the elongation phase of transcription and interacts with components of the transcription machinery. It forms part of a complex with other elongation factors helping RNA polymerase II proceed along DNA without stalling. ELOF1 ensures efficient synthesis of messenger RNA affecting the transcriptional output of numerous genes across different cellular processes.

Pathways

The influence of ELOF1 extends to key transcriptional and signaling pathways like the mRNA processing pathway. ELOF1 also connects closely to other transcription elongation factors like SPT6 affecting how cells respond to transcriptional cues. These connections are significant in maintaining proper gene regulation and expression in reaction to various intracellular signals.

ELOF1's interplay with transcription regulation links it to cancer and neurodegenerative diseases. Changes in ELOF1 expression or function can disrupt normal transcriptional elongation contributing to the uncontrolled growth of cancer cells. Additionally dysfunction in ELOF1 influences neurodegenerative processes likely through its regulatory effect on gene expression. It is associated with proteins like RNA polymerase II which play roles in these disease pathways.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

See full target information ELOF1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 12:7437-7450 PubMed31686849

2019

Ultrasound-microbubbles-mediated microRNA-449a inhibits lung cancer cell growth via the regulation of Notch1.

Applications

Unspecified application

Species

Unspecified reactive species

Lingwu Meng,Shaofei Yuan,Linjia Zhu,Zongxiao ShangGuan,Renguo Zhao

View all publications

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Anti-ELOF1抗体

Anti-ELOF1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ELOF1 antibody (AB130402)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOF1 antibody (AB130402)