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Cell Biology Apoptosis Phagocytosis

Anti-ELMO2抗体(ab2240)

  • Datasheet
Submit a review Submit a question References (7)

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Western blot - Anti-ELMO2 antibody (ab2240)

    Key features and details

    • Goat polyclonal to ELMO2
    • Suitable for: IHC-P, WB
    • Reacts with: Human
    • Isotype: IgG

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    概述

    • 产品名称

      Anti-ELMO2抗体
      参阅全部 ELMO2 一抗
    • 描述

      山羊多克隆抗体to ELMO2
    • 宿主

      Goat
    • 经测试应用

      适用于: IHC-P, WBmore details
    • 种属反应性

      与反应: Human
      预测可用于: Mouse, Rat, Cow, Dog, Pig
    • 免疫原

      Synthetic peptide: PKEPSSYDFVYHYG, corresponding to C terminal amino acids 707-720 of Human ELMO2.

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
    • 存储溶液

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 0.05% Tris, 0.5% BSA
    • Concentration information loading...
    • 纯度

      Immunogen affinity purified
    • 纯化说明

      Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Cell Biology
      • Apoptosis
      • Phagocytosis
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Apoptosis
      • Cancer
      • Cell Death
      • Apoptosis
      • Phagocytosis
      • Cancer
      • Cell Death
      • Apoptosis
      • Metabolism

    相关产品

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)
    • Recombinant Protein

      • Recombinant Human ELMO2 protein (ab131840)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab2240于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    IHC-P
    Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    WB
    Use a concentration of 1 - 3 µg/ml.

    1 hour primary incubation is recommended for this product.

    说明
    IHC-P
    Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    WB
    Use a concentration of 1 - 3 µg/ml.

    1 hour primary incubation is recommended for this product.

    靶标

    • 功能

      Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
    • 组织特异性

      Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
    • 序列相似性

      Contains 1 ELMO domain.
      Contains 1 PH domain.
    • 细胞定位

      Cytoplasm. Cytoplasm > cytosol. Membrane.
    • Target information above from: UniProt accession Q96JJ3 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 508361 Cow
      • Entrez Gene: 63916 Human
      • Entrez Gene: 140579 Mouse
      • Entrez Gene: 362271 Rat
      • Omim: 606421 Human
      • SwissProt: A4FUD6 Cow
      • SwissProt: Q96JJ3 Human
      • SwissProt: Q8BHL5 Mouse
      • Unigene: 210469 Human
      • Unigene: 35064 Mouse
      see all
    • 别名

      • CED 12 antibody
      • Ced 12 homolog 2 antibody
      • CED 12 homolog A antibody
      • CED 12A antibody
      • CED-12 antibody
      • ced-12 homolog 2 antibody
      • CED12 antibody
      • CED12 homolog A antibody
      • CED12, C. elegans, homolog of, 2 antibody
      • CED12A antibody
      • ELMO 2 antibody
      • ELMO-2 antibody
      • ELMO2 antibody
      • ELMO2_HUMAN antibody
      • Engulfment and cell motility 2 (ced 12 homolog, C. elegans) antibody
      • Engulfment and cell motility 2 antibody
      • Engulfment and cell motility gene 2 antibody
      • Engulfment and cell motility protein 2 antibody
      • FLJ11656 antibody
      • hCED 12A antibody
      • hCED-12A antibody
      • hCED12A antibody
      • KIAA1834 antibody
      • OTTHUMP00000031762 antibody
      • PH domain protein CED12A antibody
      • Protein ced 12 homolog A antibody
      • Protein ced-12 homolog A antibody
      see all

    图片

    • Western blot - Anti-ELMO2 antibody (ab2240)
      Western blot - Anti-ELMO2 antibody (ab2240)
      Ab2240 staining (2µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 12 hour.  Detected by western blot using chemiluminescence. Ab2240 staining (2µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.

    实验方案

    • Western blot protocols
    • Immunohistochemistry protocols
    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    数据表及文件

    • Datasheet download

      Download

    文献 (7)

    发表研究结果有使用 ab2240?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab2240 被引用在 7 文献中.

    • Wang Y  et al. ELMO2 association with Gai2 regulates pancreatic cancer cell chemotaxis and metastasis. PeerJ 8:e8910 (2020). PubMed: 32292657
    • Hetmanski JHR  et al. Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration. Dev Cell 51:460-475.e10 (2019). PubMed: 31607653
    • Toret CP  et al. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol 204:265-79 (2014). ICC/IF, WB ; Drosophila melanogaster . PubMed: 24446484
    • Toret CP  et al. An Elmo-Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion. J Cell Biol 207:577-87 (2014). PubMed: 25452388
    • Harada K  et al. Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase. Exp Cell Res 317:1701-13 (2011). WB ; Human . PubMed: 21621533
    • Hiramoto-Yamaki N  et al. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J Cell Biol 190:461-77 (2010). WB ; Human . PubMed: 20679435
    • Gekonge BN  et al. Signal transduction induced by apoptotic cells inhibits HIV transcription in monocytes/macrophages. J Leukoc Biol 80:953-60 (2006). WB . PubMed: 16885500

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