AB125233

Anti-EDA 抗体

Anti-EDA antibody

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(1 Publication)

Rabbit Polyclonal EDA antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EDA.

查看别名

ED1, EDA2, EDA, Ectodysplasin-A, Ectodermal dysplasia protein, EDA protein

1 Images

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Western blot - Anti-EDA antibody (AB125233)

All lanes:

Western blot - Anti-EDA antibody (ab125233) at 1 µg/mL

All lanes:

SW620 Cell Lysate

Predicted band size: 41 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human EDA. The exact immunogen used to generate this antibody is proprietary information.

Q92838

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

EDA also known as Ectodysplasin A is a protein encoded by the EDA gene. It is a member of the tumor necrosis factor (TNF) family and is expressed in epithelial cells. The molecular mass of EDA is approximately 47 kDa. EDA plays a mechanical role in signaling processes that are important for developmental pathways. Its expression is observed in tissues like skin hair follicles and some glandular cells where it contributes to cellular communication.

Biological function summary

Ectodysplasin A influences the development and differentiation of epithelial tissues. It plays a role in the formation of hair shafts sweat glands and other ectodermal structures. EDA operates as part of a signaling complex influencing cell fate decisions through binding to its receptor EDA receptor (EDAR). This interaction initiates processes for the development and maintenance of these structures impacting cell proliferation and differentiation.

Pathways

Not only does EDA interact in the TNF signaling pathway it also engages in the NF-kB pathway. The NF-kB pathway initiates transcription of genes responsible for cell survival and inflammatory responses. EDA interaction with EDAR also involves signaling pathways intersecting with NF-kB leading to activation of downstream proteins like TRAF6 and NEMO. These proteins orchestrate cell proliferation and apoptotic regulation confirming EDA's role in strategic developmental and signaling pathways.

Abnormal function or mutations in EDA link to conditions such as X-linked hypohidrotic ectodermal dysplasia (XLHED) and immune system irregularities. XLHED occurs due to EDA gene mutations leading to missing or improperly developed ectodermal structures like hair and teeth. EDA's association with XLHED connects it to EDAR and down to other proteins such as NF-kB indicating the broader genetic mutations' impact on downstream signaling which results in specific phenotype alterations seen in the disorder.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed : 11039935, PubMed : 27144394, PubMed : 34582123, PubMed : 8696334). May also play a role in cell adhesion (By similarity).. Isoform 1. Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R.. Isoform 3. Binds only to the receptor EDA2R.

See full target information EDA

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 17:4688-4694 PubMed29344666

2018

Let-7b regulates alpaca hair growth by downregulating ectodysplasin A.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Liu,Shu Niu,Xiao-Rui Cao,Jia-Qi Cheng,Shu-Yuan Gao,Xiu-Ju Yu,Hai-Dong Wang,Chang-Sheng Dong,Xiao-Yan He

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Anti-EDA 抗体

Anti-EDA antibody

Western blot - Anti-EDA antibody (AB125233)