Anti-EBV LMP2A抗体[15F9] (ab59028)
Key features and details
- Rat monoclonal [15F9] to EBV LMP2A
- Suitable for: WB, IHC-P
- Isotype: IgG1
概述
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产品名称
Anti-EBV LMP2A抗体[15F9] -
描述
大鼠单克隆抗体[15F9] to EBV LMP2A -
宿主
Rat -
特异性
ab59028 recognises LMP2A and does not cross react with LMP2B. -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Epstein-Barr virus -
免疫原
Bacterial TrpE-LMP2A fusion protein
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阳性对照
- Hodgkin’s Disease
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Protein G purified -
纯化说明
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. -
克隆
单克隆 -
克隆编号
15F9 -
骨髓瘤
P3x63-Ag8.653 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab59028于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/100 - 1/1000.
|
|
| IHC-P |
Use at an assay dependent dilution.
|
| 说明 |
|---|
|
WB
1/100 - 1/1000. |
|
IHC-P
Use at an assay dependent dilution. |
靶标
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相关性
Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. -
数据库链接
- SwissProt: P13285 Epstein-Barr virus
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别名
- EBV latent membrane protein 2A antibody
- Epstein Barr virus antibody
- HHV4 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (12)
ab59028 被引用在 12 文献中.
- Liu W et al. Epstein-Barr Virus Regulates Endothelin-1 Expression through the ERK/FOXO1 Pathway in EBV-Associated Gastric Cancer. Microbiol Spectr 11:e0089822 (2023). PubMed: 36475746
- Xu M et al. Establishment and characterization of two Epstein-Barr virus-positive gastric cancer cell lines with epitheliotropic M81 strain undergoing distinct viral and altered cellular expression profiles. J Med Virol 95:e28387 (2023). PubMed: 36478267
- Guo R et al. Methionine metabolism controls the B cell EBV epigenome and viral latency. Cell Metab 34:1280-1297.e9 (2022). PubMed: 36070681
- Granai M et al. Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program. Infect Agent Cancer 15:28 (2020). PubMed: 32391073
- Guo R et al. DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression. Nat Microbiol 5:1051-1063 (2020). PubMed: 32424339