AB16127

Anti-EBNA 3B抗体

Name: EBNA 3B抗体 (ab16127)| Abcam中文官网
Brand: Abcam Limited
SKU: AB16127
Price: 4606 CNY
Availability: InStock

Anti-EBNA 3B antibody

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(2 Publications)

Sheep Polyclonal EBNA4 antibody. Suitable for ICC, ELISA, Dot, WB, IHC-P and reacts with Epstein-Barr virus samples. Cited in 2 publications.

查看别名

BERF2A-BERF2B, EBNA4, Epstein-Barr nuclear antigen 4, EBNA-4, EBV nuclear antigen 4, Epstein-Barr nuclear antigen 3B, EBNA-3B, EBV nuclear antigen 3B

关键信息

宿主种属

Sheep

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Epstein-Barr virus

应用

WB, ICC, ELISA, Dot, IHC-P

applications

特异性

This antibody is specific for the Epstein Barr Virus Nuclear Antigen 3B.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry paraffin embedded sections", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Epstein-Barr virus": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Precipitation Ammonium Sulphate

纯化说明

Purified by ammonium sulfate precipitationThis antibody is provided as a 0.2µm sterile filtered solution.

存储溶液

Preservative: 0.08% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Epstein-Barr nuclear antigen 3B often referred to as EBNA 3B is a protein expressed by the Epstein-Barr virus (EBV). This protein is encoded within the EBV genome and shows an approximate molecular weight of 115 kDa. EBNA 3B is mainly expressed in EBV-infected B cells and plays a role in modulating the viral latent phase. It acts as a transcriptional regulator influencing the expression of both viral and host genes. Researchers also know the target by its role in latency and cellular transformation distinguishing it from other EBNA proteins.

Biological function summary

EBNA 3B contributes to the persistence of the virus in the host by modulating immune responses. It belongs to the EBNA 3 family which includes EBNA 3A and EBNA 3C forming a complex important for proper function. EBNA 3B modifies the host's cell cycle control and apoptosis aiding to maintain the viral latency essential for EBV survival and replication. This manipulation of the host cell environment ensures EBV evasion from immune system detection solidifying its role in persistent infection.

Pathways

EBNA 3B significantly influences the cell cycle and apoptosis pathways. It interacts with other EBNA proteins such as EBNA 2 and EBNA-LP in the Notch signaling pathway which plays an essential role in cell fate determination and immune response regulation. Through the modulation of these pathways EBNA 3B helps facilitate the long-term survival and proliferation of infected B cells. It supports a balance between viral latency and the risk of oncogenic transformation indicative of its strategic role in viral pathobiology.

EBNA 3B shows associations with lymphoproliferative disorders and certain types of cancers such as Burkitt's lymphoma. The protein establishes connections with other EBNA components like EBNA 1 and EBNA 2 which contribute to the oncogenic potential of EBV. These interactions can result in the deregulation of cellular growth and differentiation pathways promoting abnormal cell proliferation. Studies aim to better understand EBNA 3B's involvement in these conditions as targeting EBNA proteins holds therapeutic potential in EBV-related malignancies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May be involved in transcriptional regulation of both viral and cellular genes by interacting with the host DNA-binding protein RBPJ.

See full target information EBNA4

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1013410 PubMed40773523

2025

E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks.

Applications

Unspecified application

Species

Unspecified reactive species

Joyanta Biswas,Sk Asif Ali,Samaresh Malik,Subhadeep Nag,Piyali Mukherjee,Abhik Saha

PLoS pathogens 16:e1008105 PubMed32092124

2020

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chandrima Gain,Samaresh Malik,Shaoni Bhattacharjee,Arijit Ghosh,Erle S Robertson,Benu Brata Das,Abhik Saha

View all publications

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Anti-EBNA 3B抗体

Anti-EBNA 3B antibody