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AB16126

Anti-EBNA 3A抗体

Anti-EBNA 3A antibody

4

(1 Review)

|

(12 Publications)

Sheep Polyclonal EBNA3 antibody. Suitable for WB, ICC, Dot, ELISA, IHC-Fr and reacts with Epstein-Barr virus samples. Cited in 12 publications.

查看别名

EBV, Epstein Barr virus, HHV4, Nuclear antigen EBNA 3A

1 Images
Western blot - Anti-EBNA 3A antibody (AB16126)
  • WB

Supplier Data

Western blot - Anti-EBNA 3A antibody (AB16126)

All lanes:

Western blot - Anti-EBNA 3A antibody (ab16126)

All lanes:

Cell line infected with Epstein Barr virus.

Predicted band size: 102 kDa

false

关键信息

宿主种属

Sheep

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Epstein-Barr virus

应用

ICC, Dot, WB, IHC-Fr, ELISA

applications

特异性

This antibody is specific for the Epstein Barr Virus Nuclear Antigen 3A.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Epstein-Barr virus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.25000-1 µg/mL", "WB-species-notes": "<p></p>", "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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产品详情

Sheep were immunized with recombinant EBNA-3A protein
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性能和储存信息

形式
Liquid
纯化工艺
Precipitation Ammonium Sulphate
纯化说明
Purified by ammonium sulfate precipitation.This antibody is provided as a 0.2µm sterile filtered solution.
存储溶液
Preservative: 0.08% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

EBNA 3A also known as Epstein-Barr Nuclear Antigen 3A is a protein associated with the Epstein-Barr virus (EBV). This protein has a mass of approximately 115 kDa and is expressed in host cells infected with EBV. EBNA 3A functions as a transcriptional regulator by interacting with DNA and modulating gene expression. EBNA 3A is critical for viral latency and is expressed within the nuclei of infected B lymphocytes contributing to the persistence of the virus within host cells.
Biological function summary

EBNA 3A modulates the host cell cycle and contributes to the immortalization of infected B cells. EBNA 3A EBNA 3B and EBNA 3C form a complex that regulates viral and cellular genes. This complex plays roles in transcriptional repression and activation affecting cell growth and transformation. Through these mechanisms EBNA 3A influences immune evasion by the virus as EBV can maintain a state of latency and avoid detection by the host immune system.

Pathways

EBNA 3A participates in the regulation of the cell cycle and immune signaling. EBNA 3A affects pathways such as the Notch signaling pathway and can alter interactions with proteins like RBP-Jκ. These pathways are important for the control of gene expression and cell differentiation in infected cells. By influencing these pathways EBNA 3A helps EBV manipulate host cell behaviors to support viral replication and persistence.

EBNA 3A is linked to conditions like Burkitt's lymphoma and Hodgkin's lymphoma. These cancers are associated with the transformation of B cells resulting from EBV infection and EBNA 3A collaborates with other viral proteins such as EBNA-LP to contribute to the oncogenic processes. The presence and activity of EBNA 3A in these lymphomas suggest that targeting this protein could offer potential therapeutic avenues for managing EBV-related malignancies.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

See full target information EBNA 3A
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文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed36878637

2023

Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies.

Applications

Unspecified application

Species

Unspecified reactive species

Priya Saikumar Lakshmi,Cliff I Oduor,Catherine S Forconi,Viriato M'Bana,Courtney Bly,Rachel M Gerstein,Juliana A Otieno,John M Ong'echa,Christian Münz,Micah A Luftig,Michael A Brehm,Jeffrey A Bailey,Ann M Moormann

Anticancer research 40:5951-5968 PubMed33109533

2020

EBV Positivity and Programmed Death-ligand 1 Expression in Diffuse Large B-cell Lymphoma: A Systematic Review.

Applications

Unspecified application

Species

Unspecified reactive species

Gabriela Anna Barzyk,Vafie Sheriff

PLoS pathogens 16:e1008105 PubMed32092124

2020

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chandrima Gain,Samaresh Malik,Shaoni Bhattacharjee,Arijit Ghosh,Erle S Robertson,Benu Brata Das,Abhik Saha

Nucleic acids research 47:2807-2821 PubMed30649516

2019

Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C.

Applications

Unspecified application

Species

Unspecified reactive species

Kostas Paschos,Quentin Bazot,Jonathan Lees,Paul J Farrell,Martin J Allday

Journal of virology 92: PubMed30135119

2018

Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of and the Locus via Interaction with the Histone Lysine Demethylase KDM2B.

Applications

Unspecified application

Species

Unspecified reactive species

Adam C T Gillman,Gillian Parker,Martin J Allday,Quentin Bazot

Journal of virology 92: PubMed29367247

2018

Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the Gene in B Cells Infected by EBV.

Applications

Unspecified application

Species

Unspecified reactive species

Quentin Bazot,Kostas Paschos,Martin J Allday

PLoS pathogens 14:e1006890 PubMed29462212

2018

Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Szymula,Richard D Palermo,Amr Bayoumy,Ian J Groves,Mohammed Ba Abdullah,Beth Holder,Robert E White

Cell host & microbe 22:61-73.e7 PubMed28704654

2017

Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Donal McHugh,Nicole Caduff,Mario Henrique M Barros,Patrick C Rämer,Ana Raykova,Anita Murer,Vanessa Landtwing,Isaak Quast,Christine T Styles,Michael Spohn,Adeola Fowotade,Henri-Jacques Delecluse,Alexandra Papoudou-Bai,Yong-Moon Lee,Jin-Man Kim,Jaap Middeldorp,Thomas F Schulz,Ethel Cesarman,Andrea Zbinden,Riccarda Capaul,Robert E White,Martin J Allday,Gerald Niedobitek,David J Blackbourn,Adam Grundhoff,Christian Münz

PloS one 10:e0136476 PubMed26361042

2015

PD-1 Blockade Can Restore Functions of T-Cells in Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma In Vitro.

Applications

IHC-P

Species

Human

Lina Quan,Xue Chen,Aichun Liu,Yan Zhang,Xiuchen Guo,Shujie Yan,Yue Liu

PLoS pathogens 11:e1005031 PubMed26153983

2015

Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2.

Applications

Unspecified application

Species

Unspecified reactive species

Quentin Bazot,Kostas Paschos,Lenka Skalska,Jens S Kalchschmidt,Gillian A Parker,Martin J Allday
View all publications
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