AB189199

Anti-E-Syt1抗体

Name: E-Syt1抗体 (ab189199)| Abcam中文官网
Brand: Abcam Limited
SKU: AB189199
Price: 4606 CNY
Availability: InStock

Anti-E-Syt1 antibody

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(1 Publication)

Goat Polyclonal E-Syt1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ESYT1 aa 1000-1050.

查看别名

FAM62A, KIAA0747, MBC2, ESYT1, Extended synaptotagmin-1, E-Syt1, Membrane-bound C2 domain-containing protein

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-E-Syt1 antibody (AB189199)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-E-Syt1 antibody (AB189199)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling E-Syt1 with ab189199 at 3.75 μg/ml.

Supplier Data

Western blot - Anti-E-Syt1 antibody (AB189199)

All lanes:

Western blot - Anti-E-Syt1 antibody (ab189199) at 0.5 µg/mL

All lanes:

Human Adipose lysate (in RIPA buffer) at 35 µg

Predicted band size: 123 kDa

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关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human ESYT1 aa 1000-1050. The exact immunogen used to generate this antibody is proprietary information.

Q9BSJ8

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-3 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

E-Syt1 also known as Extended Synaptotagmin 1 is a protein encoding a molecule of approximately 129 kDa. This protein plays an essential role in the tethering of the endoplasmic reticulum (ER) to the plasma membrane facilitating lipid transfer between these organelles. It is mostly expressed in the brain and other tissues. E-Syt1 possesses N-terminal transmembrane segments that anchor it within the ER membrane and its C-terminal part reaches out to bind PI(45)P2 at the plasma membrane upon increased cytosolic calcium levels.

Biological function summary

The Extended Synaptotagmin family which includes E-Syt1 forms a complex known as the E-Syt1/SMP complex which aids in the transfer of lipids for membrane repair and cellular homeostasis. The protein ensures cell membrane integrity by shuttling lipids in response to cellular signals. This mechanism supports cell survival and function especially under stress conditions where membrane damage may occur.

Pathways

E-Syt1 is integral to phosphoinositide and calcium signaling processes. It forms important interactions within the phosphoinositide metabolism pathway facilitating membrane dynamics. The protein also intersects with pathways involving calcium signaling due to its calcium-binding capacity working alongside proteins like Synaptotagmin to fine-tune cellular responses to fluctuations in calcium levels.

Extended Synaptotagmin 1 has implications in conditions like neurodegenerative diseases and certain cancers. Alterations in E-Syt1 activity or expression levels can contribute to conditions such as Alzheimer’s disease where disrupted lipid transport affects neuronal health. E-Syt1 in tandem with proteins like tau in Alzheimer’s highlights its role in maintaining cellular functions that prevent disease progression. Its involvement in lipid transfer can also relate to cancer pathologies where cell membrane dynamics are important.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed : 23791178, PubMed : 24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed : 24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed : 38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity).

See full target information ESYT1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Translational lung cancer research 14:1351-1370 PubMed40386722

2025

was stabilized through N-methyladenosine methylation and exerted its anticancer effects in lung squamous cell carcinoma by inhibiting SIRT1 activity via CCAR2.

Applications

Unspecified application

Species

Unspecified reactive species

Qihang Yan,Wingshing Wong,Jinsong Lei,Dachuan Liang,Jie Yang,Li Gong,Rossana Berardi,Shuqin Dai,Junye Wang

View all publications

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Anti-E-Syt1抗体

Anti-E-Syt1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-E-Syt1 antibody (AB189199)

Western blot - Anti-E-Syt1 antibody (AB189199)