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AB15108

Anti-Dysferlin抗体

Anti-Dysferlin antibody

3

(4 Reviews)

|

(5 Publications)

Rabbit Polyclonal Dysferlin antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications.

查看别名

FER1L1, DYSF, Dysferlin, Dystrophy-associated fer-1-like protein, Fer-1-like protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dysferlin antibody (AB15108)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dysferlin antibody (AB15108)

ab15108 staining Dysferlin in human skeletal muscle by Immunohistochemistry (FFPE-sections).

Western blot - Anti-Dysferlin antibody (AB15108)
  • WB

Unknown

Western blot - Anti-Dysferlin antibody (AB15108)

All lanes:

Western blot - Anti-Dysferlin antibody (ab15108) at 1 µg/mL

All lanes:

Human skeletal muscle tissue lysate - total protein (<a href='/products/unavailable/human-skeletal-muscle-tissue-lysate-total-protein-ab29330'>ab29330</a>) at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 237 kDa

Observed band size: 231 kDa,240 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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您是否考虑以下替代产品？

AB124684

Anti-Dysferlin antibody [JAI-1-49-3]

4
4 Reviews
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为什么推荐这个？

为向您提供最高品质的产品，我们在不断升级产品范围。我们选择了这个替代产品供您参考，因为它提供了更好的性能，更容易和更方便的使用，或交期更快。

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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
运输条件
Blue Ice
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Dysferlin also known by its alternate names DYSF and CAPN3 is a protein characterized by a mass of approximately 237 kilodaltons. It belongs to the ferlin family and is mainly expressed in skeletal and cardiac muscle tissues. This protein contains multiple C2 domains which are significant for its membrane-trafficking roles. Dysferlin has an important role at the muscle surface particularly in the repair of sarcolemma breaches which helps maintain muscle cell integrity.
Biological function summary

The action of dysferlin impacts several molecular processes critical for muscle function and maintenance often interacting as part of a larger protein complex. It facilitates membrane repair by promoting vesicle fusion events and recruits other proteins to damaged sites. Such action is vital in restoring cellular structure after membrane damage particularly under the mechanical stress experienced in muscle tissues.

Pathways

Dysferlin operates within the calcium-dependent membrane repair pathway and the broader muscular dystrophy pathway. It interacts importantly with proteins such as annexins and actin that aid in membrane repair processes. Dysferlin's role in cellular repair connects it to pathways related to muscle membrane dynamics and stress response further highlighting its function in muscle health and recovery.

Mutations or deficiencies in dysferlin are linked to muscular dystrophies such as limb-girdle muscular dystrophy type 2B and Miyoshi myopathy. These conditions are characterized by progressive muscle weakness and wasting. The link between dysferlin's function and these disorders is also seen in its association with proteins like calpain 3 which also plays a role in muscle maintenance. Understanding the line of interaction between dysferlin and these proteins offers insights into potential therapeutic targets for these conditions.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).
See full target information DYSF
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:6849 PubMed36369230

2022

Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Raquel Gómez-Oca,Evelina Edelweiss,Sarah Djeddi,Mathias Gerbier,Xènia Massana-Muñoz,Mustapha Oulad-Abdelghani,Corinne Crucifix,Coralie Spiegelhalter,Nadia Messaddeq,Pierre Poussin-Courmontagne,Pascale Koebel,Belinda S Cowling,Jocelyn Laporte

Frontiers in neuroscience 9:16 PubMed25729345

2015

The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions.

Applications

IHC

Species

Unspecified reactive species

Sophie Whish,Katarzyna M Dziegielewska,Kjeld Møllgård,Natassya M Noor,Shane A Liddelow,Mark D Habgood,Samantha J Richardson,Norman R Saunders

Neuromuscular disorders : NMD 20:820-5 PubMed20817457

2010

Evaluation of commercial dysferlin antibodies on canine, mouse and human skeletal muscle.

Applications

WB, WB, WB

Species

Human, Dog, Mouse

Ling T Guo,Steven A Moore,Sonia Forcales,Eva Engvall,G Diane Shelton

Human molecular genetics 18:318-27 PubMed18986978

2008

Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Angela K Peter,Christopher Y Ko,Michelle H Kim,Nigel Hsu,Noriyuki Ouchi,Suhn Rhie,Yasuhiro Izumiya,Ling Zeng,Kenneth Walsh,Rachelle H Crosbie

FASEB journal : official publication of the Federa 21:1768-76 PubMed17363620

2007

From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Lars Klinge,Steve Laval,Sharon Keers,Faye Haldane,Volker Straub,Rita Barresi,Kate Bushby
View all publications
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