AB86093

Anti-DRIM抗体

Name: DRIM抗体 (ab86093)| Abcam中文官网
Brand: Abcam Limited
SKU: AB86093
Price: 4606 CNY
Availability: InStock

Anti-DRIM antibody

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(1 Publication)

Rabbit Polyclonal DRIM antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UTP20 aa 2700 to C-terminus.

查看别名

DRIM, UTP20, Small subunit processome component 20 homolog, Down-regulated in metastasis protein, Novel nucleolar protein 73, Protein Key-1A6, NNP73

2 Images

Unknown

Immunoprecipitation - Anti-DRIM antibody (AB86093)

Detection of DRIM by Western Blot of Immunprecipitate.
ab86093 at 1µg/ml staining DRIM in HeLa whole cell lysate immunoprecipitated using ab86093 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection : Chemiluminescence with exposure time of 10 seconds.

All lanes:

Immunoprecipitation - Anti-DRIM antibody (ab86093)

Predicted band size: 318 kDa

false

Unknown

Western blot - Anti-DRIM antibody (AB86093)

All lanes:

Western blot - Anti-DRIM antibody (ab86093) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Lane 4:

293T whole cell lysate at 50 µg

Lane 5:

NIH3T3 whole cell lysate at 50 µg

Predicted band size: 318 kDa

Observed band size: 318 kDa,65 kDa

false

Exposure time: 30s

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

IP, WB

applications

免疫原

Synthetic Peptide within Human UTP20 aa 2700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O75691

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Bat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Elephant": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab86093 was affinity purified using an epitope specific to DRIM immobilized on solid support.

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The target 'DRIM' also known as Disease Resistance Interactor M is a protein involved in various cellular activities. The exact mass of DRIM remains to be fully characterized but its presence is detectable in multiple tissues especially in immune cells. Scientists have identified DRIM through intense study of immune response and stress conditions. DRIM expression is observed in tissues undergoing inflammation or infection hinting at its potential role in defense mechanisms.

Biological function summary

DRIM influences cellular responses that modulate immune defense and stress tolerance. This protein is a part of a larger complex that regulates signal transduction within immune cells. Its activity supports many defense functions by modifying how cells respond to external stress and pathogen presence. Studies suggest DRIM interacts with several cytoplasmic proteins critical for initiating immune responses putting it at the crossroads of cellular defense.

Pathways

DRIM plays a part in inflammatory and stress response pathways. It participates in the NF-kB signaling pathway helping regulate inflammation processes. DRIM relates closely with proteins like TNF-alpha and IL-1 beta linking it to the immune response cascade. These connections place DRIM as a significant player in maintaining cellular homeostasis during stress conditions.

DRIM shows relevance to autoimmune diseases and chronic inflammatory disorders. DRIM's involvement in the NF-kB pathway ties it to conditions like rheumatoid arthritis and systemic lupus erythematosus. Dysregulation of DRIM can impact proteins such as TNF-alpha contributing to persistent inflammation and immune system dysfunction. These associations underline DRIM's importance in both immune system regulation and disease pathology making it a target for further therapeutic exploration.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.

See full target information UTP20

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental eye research 148:12-23 PubMed27170050

2016

Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis.

Applications

Unspecified application

Species

Unspecified reactive species

Monica M Sauter,Curtis R Brandt

View all publications

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Anti-DRIM抗体

Anti-DRIM antibody

Immunoprecipitation - Anti-DRIM antibody (AB86093)

Western blot - Anti-DRIM antibody (AB86093)