Anti-DREAM抗体(ab3474)
Key features and details
- Rabbit polyclonal to DREAM
- Suitable for: ICC/IF
- Reacts with: Rabbit
- Isotype: IgG
概述
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产品名称
Anti-DREAM抗体
参阅全部 DREAM 一抗 -
描述
兔多克隆抗体to DREAM -
宿主
Rabbit -
特异性
Detects KChIP 3 from rabbit cerebellar granule cells. -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Rabbit
预测可用于: Mouse
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免疫原
Synthetic peptide corresponding to Mouse DREAM aa 30-45.
Sequence:IKWQRPRFTRQALMRC
(Peptide available asab5866) -
阳性对照
- ICC/IF: Rabbit granule cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
ICC/IF
Use at an assay dependent concentration. |
靶标
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功能
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. -
组织特异性
Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. -
序列相似性
Belongs to the recoverin family.
Contains 4 EF-hand domains. -
翻译后修饰
Palmitoylated. Palmitoylation enhances association with the plasma membrane.
Proteolytically cleaved by caspase-3.
Phosphorylation at Ser-63 inhibits cleavage by CASP3. -
细胞定位
Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 56461 Mouse
- SwissProt: Q9QXT8 Mouse
- Unigene: 315292 Mouse
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别名
- 4933407H12Rik antibody
- A type potassium channel modulatory protein 3 antibody
- A-type potassium channel modulatory protein 3 antibody
see all
图片
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Immunocytochemistry/ Immunofluorescence - Anti-DREAM antibody (ab3474)
Immunolocalization of DREAM in Rabbit granule cells using ab3474.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab3474 被引用在 2 文献中.
- Liang Y et al. iTRAQ-based proteomic analysis discovers potential biomarkers of diffuse axonal injury in rats. Brain Res Bull 153:289-304 (2019). PubMed: 31539556
- Tian NX et al. KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats. J Neurosci 38:1756-1773 (2018). PubMed: 29335353