Anti-DRD5抗体(ab40656)
Key features and details
- Rabbit polyclonal to DRD5
- Suitable for: ICC/IF, Flow Cyt, WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-DRD5抗体
参阅全部 DRD5 一抗 -
描述
兔多克隆抗体to DRD5 -
宿主
Rabbit -
特异性
Cross-reacts with Human D5 Dopamine Receptor(Ac23-35) 100%, D5 Dopamine Receptor 80%. Does not cross react with other dopamine receptors (D1, D2, D3, D4).
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经测试应用
适用于: ICC/IF, Flow Cyt, WBmore details -
种属反应性
与反应: Rat
预测可用于: Human, Gorilla
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免疫原
Synthetic peptide corresponding to Human DRD5 aa 23-35 (acetyl G23) conjugated to keyhole limpet haemocyanin (Cysteine residue).
Sequence: AcGNAVGGSAGAPP
Database link: P21918 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Rehydrate the lyophilized antibody with 0.1 ml of PBS which contains 10 mg/ml BSA or with additional buffer (such as 10 mg/ml BSA in PBS) for more dilute antibody. -
存放说明
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles. -
存储溶液
Constituent: Whole serum -
Concentration information loading... -
纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab40656于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use at an assay dependent concentration.
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| Flow Cyt | (1) |
Use at an assay dependent concentration.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
| WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa.
Blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. |
| 说明 |
|---|
|
ICC/IF
Use at an assay dependent concentration. |
|
Flow Cyt
Use at an assay dependent concentration. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa. Blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. |
靶标
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功能
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. -
组织特异性
Neuron-specific, localized primarily within limbic regions of the brain. -
疾病相关
Defects in DRD5 are a cause of benign essential blepharospasm (BEB) [MIM:606798]. BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 1816 Human
- Entrez Gene: 25195 Rat
- Omim: 126453 Human
- SwissProt: P21918 Human
- SwissProt: P25115 Rat
- Unigene: 380681 Human
- Unigene: 138110 Rat
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别名
- D(1B) dopamine receptor antibody
- D(5) dopamine receptor antibody
- D1 beta dopamine receptor antibody
see all
数据表及文件
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Datasheet download
文献 (2)
ab40656 被引用在 2 文献中.
- Zhu Y et al. Dopamine D1 and D3 Receptors Modulate Heroin-Induced Cognitive Impairment through Opponent Actions in Mice. Int J Neuropsychopharmacol 20:257-268 (2017). PubMed: 27815417
- Reyes S et al. Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Mov Disord 28:1351-9 (2013). PubMed: 23674405
