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AB8419

Anti-DRAK2 antibody

Anti-DRAK2 antibody

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Rabbit Polyclonal DRAK2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human STK17B aa 350 to C-terminus.

查看别名

DRAK2, STK17B, Serine/threonine-protein kinase 17B, DAP kinase-related apoptosis-inducing protein kinase 2

3 Images
Western blot - Anti-DRAK2 antibody (AB8419)
  • WB

Unknown

Western blot - Anti-DRAK2 antibody (AB8419)

Lane 1:

Western blot - Anti-DRAK2 antibody (ab8419) at 1 µg/mL

Lane 2:

Western blot - Anti-DRAK2 antibody (ab8419) at 2 µg/mL

All lanes:

Raji cell lysate

Predicted band size: 42 kDa

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Western blot - Anti-DRAK2 antibody (AB8419)
  • WB

Unknown

Western blot - Anti-DRAK2 antibody (AB8419)

We are unsure about the nature of the 70 kDa band. However, DRAK2 is autophosphorylated and it is possible that this band corresponds to the phosphorylated form. The fact that the detection of this band is blocked by DRAK2 peptide indicates that it probably is closely related to the DRAK2 protein.

All lanes:

Western blot - Anti-DRAK2 antibody (ab8419) at 1/500 dilution

Lane 1:

Jurkat whole cell lysate with absence of blocking peptide

Lane 2:

Raji whole cell lysate with absence of blocking peptide

Lane 3:

Jurkat whole cell lysate with presence of blocking peptide

Lane 4:

Raji whole cell lysate with presence of blocking peptide

Predicted band size: 42 kDa

Observed band size: 45 kDa

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Immunocytochemistry/ Immunofluorescence - Anti-DRAK2 antibody (AB8419)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DRAK2 antibody (AB8419)

ab8419 at 10μg/ml staining DRAK2 in Jurkat cells by ICC/IF

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

轻链类型

unknown

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Synthetic Peptide within Human STK17B aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O94768

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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您是否考虑以下替代产品？

AB108373

Anti-DRAK2 antibody [EPR3163Y]

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0 Reviews
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为什么推荐这个？

为向您提供最高品质的产品，我们在不断升级产品范围。我们选择了这个替代产品供您参考，因为它提供了更好的性能，更容易和更方便的使用，或交期更快。

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产品详情

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP,are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases) (1). DRAKs contain anN-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
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性能和储存信息

形式
Liquid
纯化工艺
Ion exchange chromatography
纯化说明
DRAK2 Antibody is Ion exchange chromatography purified.
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

DRAK2 also known as Death-associated protein kinase-related apoptosis-inducing protein kinase 2 is part of the serine/threonine kinase family. This protein has a molecular weight of about 48 kDa. DRAK2 expresses mostly in lymphoid tissues including the spleen and thymus. It plays a role in negative regulation during T-cell receptor signaling and is important during lymphocyte activation.
Biological function summary

The role of DRAK2 extends beyond kinase activity. It is involved in immune response modulation and can affect apoptosis in T lymphocytes. DRAK2 is not part of a larger protein complex but rather acts independently to exert its function. It influences cellular mechanisms by altering signaling pathways that impact cell survival and death.

Pathways

You find DRAK2 involved in both the T-cell receptor signaling and apoptosis pathways. It connects to the T-cell receptor pathway due to its regulation of T-cell activation and proliferation. DRAK2 activity can interact with proteins such as calmodulin and Protein Kinase C in these pathways indicating its role in signaling transduction critical for T-cell function.

DRAK2 links to autoimmune diseases and cancer. Abnormal DRAK2 expression might contribute to autoimmune conditions like multiple sclerosis by affecting T-cell autoreactivity. Its involvement in cancer emerges through regulation of apoptosis where malfunction may lead to resistance against cell death aiding cancer cell survival. In this context DRAK2 connection with proteins such as caspases plays a role in mediating apoptotic pathways in cells.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.
See full target information STK17B
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