Anti-DR6抗体(ab8417)
Key features and details
- Rabbit polyclonal to DR6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-DR6抗体
参阅全部 DR6 一抗 -
描述
兔多克隆抗体to DR6 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human DR6 aa 42-56.
Sequence:QPEQKASNLIGTYRHC
(Peptide available asab8450) -
阳性对照
- WB: HeLa and K562 whole cell lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
DEAE-Chromatography -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/500 - 1/2000. Detects a band of approximately 68 kDa.
|
| 说明 |
|---|
|
WB
1/500 - 1/2000. Detects a band of approximately 68 kDa. |
靶标
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功能
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). -
组织特异性
Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. -
序列相似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 27242 Human
- Omim: 605732 Human
- SwissProt: O75509 Human
- Unigene: 443577 Human
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别名
- TNFRSF 21 antibody
- BM 018 antibody
- BM018 antibody
see all
图片
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Western blot - Anti-DR6 antibody (ab8417)All lanes : Anti-DR6 antibody (ab8417) at 1/500 dilution
Lane 1 : K562 whole cell lysate with absence of blocking peptide
Lane 2 : Raji whole cell lysate with absence of blocking peptide
Lane 3 : K562 whole cell lysate with Human DR6 peptide (ab8450)
Lane 4 : Raji whole cell lysate with Human DR6 peptide (ab8450)
Observed band size: 68 kDa why is the actual band size different from the predicted?
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab8417 被引用在 2 文献中.
- Zhang T et al. Amyloid precursor protein binds with TNFRSF21 to induce neural inflammation in Alzheimer's Disease. Eur J Pharm Sci 157:105598 (2021). PubMed: 33075465
- Klíma M et al. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793:1579-87 (2009). WB ; Human . PubMed: 19654028