Anti-DOPA Decarboxylase/DDC抗体(ab3905)
Key features and details
- Rabbit polyclonal to DOPA Decarboxylase/DDC
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
概述
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产品名称
Anti-DOPA Decarboxylase/DDC抗体
参阅全部 DOPA Decarboxylase/DDC 一抗 -
描述
兔多克隆抗体to DOPA Decarboxylase/DDC -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat -
免疫原
Recombinant fragment corresponding to Bovine DOPA Decarboxylase/DDC. expressed in E. coli and purified from inclusion bodies
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.50
Preservative: 0.1% Sodium azide
Constituents: PBS, 0.316% Tris HCl, 0.05% Tween, 0.238% HEPES, 10% Glycerol, 0.1% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
Use a concentration of 0.1 - 0.5 µg/ml.
|
| 说明 |
|---|
|
WB
Use a concentration of 0.1 - 0.5 µg/ml. |
靶标
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功能
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. -
通路
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2. -
疾病相关
Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive. -
序列相似性
Belongs to the group II decarboxylase family. - Information by UniProt
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数据库链接
- Entrez Gene: 13195 Mouse
- Entrez Gene: 24311 Rat
- SwissProt: O88533 Mouse
- SwissProt: P14173 Rat
- Unigene: 12906 Mouse
- Unigene: 11064 Rat
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别名
- AADC antibody
- Aromatic L Amino Acid Decarboxylase antibody
- Aromatic-L-amino-acid decarboxylase antibody
see all
图片
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Western blot - Anti-DOPA Decarboxylase/DDC antibody (ab3905)Anti-DOPA Decarboxylase/DDC antibody (ab3905) + Mouse cerebellum lysate at 0.2 mg/ml
Performed under reducing conditions. -
Western blot - Anti-DOPA Decarboxylase/DDC antibody (ab3905)Anti-DOPA Decarboxylase/DDC antibody (ab3905) + Rat adrenal medulla lysate
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (26)
ab3905 被引用在 26 文献中.
- Raina A et al. Dopamine promotes the neurodegenerative potential of ß-synuclein. J Neurochem 156:674-691 (2021). PubMed: 32730640
- Heo JY et al. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. Curr Biol 30:276-291.e9 (2020). PubMed: 31928877
- Chen X et al. Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression. Aging (Albany NY) 12:3042-3052 (2020). PubMed: 32074509
- Kao CY et al. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction. PLoS Genet 16:e1008868 (2020). PubMed: 32579581
- Scott AL et al. Regulation of catecholamine release from the adrenal medulla is altered in deer mice (Peromyscus maniculatus) native to high altitudes. Am J Physiol Regul Integr Comp Physiol 317:R407-R417 (2019). PubMed: 31242021